| pubmed-article:1309295 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1309295 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:1309295 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:1309295 | lifeskim:mentions | umls-concept:C0025914 | lld:lifeskim |
| pubmed-article:1309295 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:1309295 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:1309295 | lifeskim:mentions | umls-concept:C0521447 | lld:lifeskim |
| pubmed-article:1309295 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:1309295 | lifeskim:mentions | umls-concept:C1553039 | lld:lifeskim |
| pubmed-article:1309295 | lifeskim:mentions | umls-concept:C0441712 | lld:lifeskim |
| pubmed-article:1309295 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:1309295 | pubmed:dateCreated | 1992-1-23 | lld:pubmed |
| pubmed-article:1309295 | pubmed:abstractText | Treatment of wild-type (wt) aryl hydrocarbon (Ah)-responsive mouse Hepa 1c1c7 cells with benzo[a]pyrene (B[a]P) caused a concentration-dependent induction of ethoxyresorufin O-deethylase (EROD) activity. In contrast, B[a]P was inactive as an inducer in Ah nonresponsive class 1 and class 2 mutant cell lines. In parallel experiments, the nuclear fractions from wt cells treated with 10(-7) M [3H]B[a]P contained both the 4 s carcinogen binding protein and the 6 s (Ah receptor) complexes, whereas only the 4 s complex was present in the nuclear fraction of the class 2 mutant cells. The results obtained from cotreatment of wt Hepa 1c1c7 cells with 10(-6) or 10(-7) M B[a]P and 5 x 10(-7) or 10(-7) M 6-methyl-1,3,8-trichlorodibenzofuran (MCDF) showed that MCDF inhibited the induction of EROD activity and Cyp1a-1 mRNA levels by B[a]P. Moreover, using 10(-7) M [3H]B[a]P and unlabeled MCDF, it was shown that MCDF not only inhibited the induction response but also caused a concentration-dependent decrease in levels of the nuclear 6 s complex but not the 4 s complex. In contrast, in situ competition studies with unlabeled 10(-6) M benzo[ghi]-perylene (B[ghi]P) resulted in the elimination of the nuclear [3H]B[a]P 4 s complex (but not the 6 s complex); however, the EROD activity and Cyp1a-1 mRNA levels in cells treated with 10(-7) M B[a]P in the presence or absence of 10(-6) M B[ghi]P were not significantly different. These results indicate that the 4 s binding protein is not required for the induction of Cyp1a-1 gene expression in Hepa 1c1c7 cells and suggest that B[a]P and 2,3,7,8-tetrachlorodibenzo-p-dioxin induce Cyp1a-1 gene expression via a common mechanism which involves binding to the Ah receptor. | lld:pubmed |
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| pubmed-article:1309295 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1309295 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1309295 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:1309295 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1309295 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:1309295 | pubmed:issn | 0003-9861 | lld:pubmed |
| pubmed-article:1309295 | pubmed:author | pubmed-author:SabóAA | lld:pubmed |
| pubmed-article:1309295 | pubmed:author | pubmed-author:RosengrenRR | lld:pubmed |
| pubmed-article:1309295 | pubmed:author | pubmed-author:WangXX | lld:pubmed |
| pubmed-article:1309295 | pubmed:author | pubmed-author:MerchantMM | lld:pubmed |
| pubmed-article:1309295 | pubmed:author | pubmed-author:MorrisonVV | lld:pubmed |
| pubmed-article:1309295 | pubmed:author | pubmed-author:KampsCC | lld:pubmed |
| pubmed-article:1309295 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1309295 | pubmed:volume | 292 | lld:pubmed |
| pubmed-article:1309295 | pubmed:geneSymbol | Cyp1a-1 | lld:pubmed |
| pubmed-article:1309295 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1309295 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1309295 | pubmed:pagination | 250-7 | lld:pubmed |
| pubmed-article:1309295 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:1309295 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1309295 | pubmed:articleTitle | Mechanism of benzo[a]pyrene-induced Cyp1a-1 gene expression in mouse Hepa 1c1c7 cells: role of the nuclear 6 s and 4 s proteins. | lld:pubmed |
| pubmed-article:1309295 | pubmed:affiliation | Department of Veterinary Physiology and Pharmacology, Texas A&M University, College Station 77843. | lld:pubmed |
| pubmed-article:1309295 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1309295 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:1309295 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1309295 | lld:pubmed |
