| pubmed-article:1301798 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1301798 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:1301798 | lifeskim:mentions | umls-concept:C1299003 | lld:lifeskim |
| pubmed-article:1301798 | lifeskim:mentions | umls-concept:C0021390 | lld:lifeskim |
| pubmed-article:1301798 | lifeskim:mentions | umls-concept:C0032952 | lld:lifeskim |
| pubmed-article:1301798 | lifeskim:mentions | umls-concept:C0600688 | lld:lifeskim |
| pubmed-article:1301798 | lifeskim:mentions | umls-concept:C1521725 | lld:lifeskim |
| pubmed-article:1301798 | pubmed:issue | 3-4 | lld:pubmed |
| pubmed-article:1301798 | pubmed:dateCreated | 1993-6-9 | lld:pubmed |
| pubmed-article:1301798 | pubmed:abstractText | We performed ocular examinations on 58 corticosteroid-treated pediatric patients with inflammatory bowel disease (IBD) and on 58 age-matched controls. Posterior subcapsular cataracts (PSC) were detected in 12 of the 58 treated patients (20.7%) and in none of the controls. The difference in mean intraocular pressure (IOP) between the treated patients (15.89 +/- 4.11 mm Hg) and control subjects (13.63 +/- 2.35 mm Hg) was significant statistically (P < 0.001). Twenty-one patients (36.2%) were characterized as "IOP responders" (IOP > or = 20 mm Hg, change in IOP > or = 6 mm Hg between visits, or a difference in IOP > or = 6 mm Hg between the two eyes). Formation of PSC was not correlated significantly (P > 0.05) with the total dose of prednisone, duration of treatment, average daily dose, or number of days on high doses (> or = 25 mg). Raised IOP was correlated (P = 0.005) only with average daily dose (12.4 +/- 10.9 mg/day; range, 0-47 mg/day) 30 days before examination. When the dose of corticosteroid was reduced to < 10 mg/day, 2 patients manifested regression of PSC, and 12 IOP responders showed a decrease in IOP to within 2 SD of the mean control IOP. Only 3 of the 58 treated patients (5.2%) manifested both PSC and raised IOP. A significant inverse correlation (P = 0.02) was established between IOP at first examination and formation of PSC. We propose that the mechanisms for steroid-induced lens opacities and raised IOP do not share the same genetic basis. Because 52% of these children developed either PSC or raised IOP with prednisone therapy, we advocate careful ophthalmologic monitoring of pediatric patients receiving corticosteroids for IBD or any other condition. | lld:pubmed |
| pubmed-article:1301798 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1301798 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1301798 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1301798 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1301798 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1301798 | pubmed:issn | 1042-6922 | lld:pubmed |
| pubmed-article:1301798 | pubmed:author | pubmed-author:TripathiR CRC | lld:pubmed |
| pubmed-article:1301798 | pubmed:author | pubmed-author:ErnestJ TJT | lld:pubmed |
| pubmed-article:1301798 | pubmed:author | pubmed-author:KirschnerB... | lld:pubmed |
| pubmed-article:1301798 | pubmed:author | pubmed-author:TripathiB JBJ | lld:pubmed |
| pubmed-article:1301798 | pubmed:author | pubmed-author:ShevellS KSK | lld:pubmed |
| pubmed-article:1301798 | pubmed:author | pubmed-author:LIANO KOK | lld:pubmed |
| pubmed-article:1301798 | pubmed:author | pubmed-author:BorisuthN SNS | lld:pubmed |
| pubmed-article:1301798 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1301798 | pubmed:volume | 9 | lld:pubmed |
| pubmed-article:1301798 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1301798 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1301798 | pubmed:pagination | 469-82 | lld:pubmed |
| pubmed-article:1301798 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:1301798 | pubmed:meshHeading | pubmed-meshheading:1301798-... | lld:pubmed |
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| pubmed-article:1301798 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1301798 | pubmed:articleTitle | Ocular toxicity of prednisone in pediatric patients with inflammatory bowel disease. | lld:pubmed |
| pubmed-article:1301798 | pubmed:affiliation | Visual Sciences Center, University of Chicago, IL 60637. | lld:pubmed |
| pubmed-article:1301798 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1301798 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
