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pubmed-article:12973930pubmed:abstractTextTo study the expression of peroxisome proliferator-activated receptor-gamma (PPAR-gamma) in lung cancer cells, and to testify if the PPAR-gamma agonists can inhibit human lung cancer cell growth through induction of apoptosis, PPAR-gamma was detected in two lung cancer cell lines by RT-PCR and immunohistochemistry, the inhibition of human lung cancer cell growth was investigated by MTT and cell counts, and the apoptosis was assessed by TUNEL. The results showed that: (1) PPAR-gamma expressed on two lung cancer cell lines; (2) PPAR-gamma activated by ligands could inhibit human lung cancer cell growth remarkably; (3) PPAR-gamma agonists could induce apoptosis to inhibit lung cancer cell growth. It was concluded that PPAR-gamma expressed in lung cancer cell can be activated by ligands and can inhibit lung cancer cell growth through induction of apoptosis.lld:pubmed
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pubmed-article:12973930pubmed:dateRevised2006-12-14lld:pubmed
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pubmed-article:12973930pubmed:articleTitlePeroxisome proliferator-activated receptor-gamma activated by ligands can inhibit human lung cancer cell growth through induction of apoptosis.lld:pubmed
pubmed-article:12973930pubmed:affiliationInstitute of Hematology, Xiehe Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022.lld:pubmed
pubmed-article:12973930pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:12973930pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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