Linked Life Data

12956872

Source:http://linkedlifedata.com/resource/pubmed/id/12956872

Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:12956872rdf:typepubmed:Citationlld:pubmed
pubmed-article:12956872lifeskim:mentionsumls-concept:C1705014lld:lifeskim
pubmed-article:12956872lifeskim:mentionsumls-concept:C0025252lld:lifeskim
pubmed-article:12956872lifeskim:mentionsumls-concept:C0002812lld:lifeskim
pubmed-article:12956872lifeskim:mentionsumls-concept:C0596119lld:lifeskim
pubmed-article:12956872lifeskim:mentionsumls-concept:C2700116lld:lifeskim
pubmed-article:12956872pubmed:issue10lld:pubmed
pubmed-article:12956872pubmed:dateCreated2003-9-5lld:pubmed
pubmed-article:12956872pubmed:abstractTextAn expression screen of a rat cDNA library for sequences encoding Golgi-localized integral membrane proteins identified a protein with an apparent novel topology, i.e. with both an N-terminal transmembrane domain and a C-terminal glycosyl-phosphatidylinositol (GPI) anchor. Our data are consistent with this. Thus, the protein would have a topology that, in mammalian cells, is shared only by a minor, but pathologically important, topological isoform of the prion protein (PrP). The human orthologue of this protein has been described previously (BST-2 or HM1.24 antigen) as a cell surface molecule that appears to be involved in early pre-B-cell development and which is present at elevated levels at the surface of myeloma cells. We show that rat BST-2/HM1.24 has both a cell surface and an intracellular (juxtanuclear) location and is efficiently internalized from the cell surface. We also show that the cell surface pool of BST-2/HM1.24 is predominantly present in the apical plasma membrane of polarized cells. The fact that rat BST-2/HM1.24 apparently possesses a GPI anchor led us to speculate that it might exist in cholesterol-rich lipid microdomains (lipid rafts) at the plasma membrane. Data from several experiments are consistent with this localization. We present a model in which BST-2/HM1.24 serves to link adjacent lipid rafts within the plasma membrane.lld:pubmed
pubmed-article:12956872pubmed:languageenglld:pubmed
pubmed-article:12956872pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12956872pubmed:citationSubsetIMlld:pubmed
pubmed-article:12956872pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12956872pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12956872pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12956872pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12956872pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12956872pubmed:statusMEDLINElld:pubmed
pubmed-article:12956872pubmed:monthOctlld:pubmed
pubmed-article:12956872pubmed:issn1398-9219lld:pubmed
pubmed-article:12956872pubmed:authorpubmed-author:BantingGeorge...lld:pubmed
pubmed-article:12956872pubmed:authorpubmed-author:WildeAndrewAlld:pubmed
pubmed-article:12956872pubmed:authorpubmed-author:KupzigSabineSlld:pubmed
pubmed-article:12956872pubmed:authorpubmed-author:KorolchukVikt...lld:pubmed
pubmed-article:12956872pubmed:authorpubmed-author:RollasonRuthRlld:pubmed
pubmed-article:12956872pubmed:authorpubmed-author:SugdenAnnaAlld:pubmed
pubmed-article:12956872pubmed:issnTypePrintlld:pubmed
pubmed-article:12956872pubmed:volume4lld:pubmed
pubmed-article:12956872pubmed:ownerNLMlld:pubmed
pubmed-article:12956872pubmed:authorsCompleteYlld:pubmed
pubmed-article:12956872pubmed:pagination694-709lld:pubmed
pubmed-article:12956872pubmed:dateRevised2010-11-18lld:pubmed
pubmed-article:12956872pubmed:meshHeadingpubmed-meshheading:12956872...lld:pubmed
pubmed-article:12956872pubmed:meshHeadingpubmed-meshheading:12956872...lld:pubmed
pubmed-article:12956872pubmed:meshHeadingpubmed-meshheading:12956872...lld:pubmed
pubmed-article:12956872pubmed:meshHeadingpubmed-meshheading:12956872...lld:pubmed
pubmed-article:12956872pubmed:meshHeadingpubmed-meshheading:12956872...lld:pubmed
pubmed-article:12956872pubmed:meshHeadingpubmed-meshheading:12956872...lld:pubmed
pubmed-article:12956872pubmed:meshHeadingpubmed-meshheading:12956872...lld:pubmed
pubmed-article:12956872pubmed:meshHeadingpubmed-meshheading:12956872...lld:pubmed
pubmed-article:12956872pubmed:meshHeadingpubmed-meshheading:12956872...lld:pubmed
pubmed-article:12956872pubmed:meshHeadingpubmed-meshheading:12956872...lld:pubmed
pubmed-article:12956872pubmed:meshHeadingpubmed-meshheading:12956872...lld:pubmed
pubmed-article:12956872pubmed:meshHeadingpubmed-meshheading:12956872...lld:pubmed
pubmed-article:12956872pubmed:meshHeadingpubmed-meshheading:12956872...lld:pubmed
pubmed-article:12956872pubmed:meshHeadingpubmed-meshheading:12956872...lld:pubmed
pubmed-article:12956872pubmed:meshHeadingpubmed-meshheading:12956872...lld:pubmed
pubmed-article:12956872pubmed:meshHeadingpubmed-meshheading:12956872...lld:pubmed
pubmed-article:12956872pubmed:meshHeadingpubmed-meshheading:12956872...lld:pubmed
pubmed-article:12956872pubmed:meshHeadingpubmed-meshheading:12956872...lld:pubmed
pubmed-article:12956872pubmed:meshHeadingpubmed-meshheading:12956872...lld:pubmed
pubmed-article:12956872pubmed:meshHeadingpubmed-meshheading:12956872...lld:pubmed
pubmed-article:12956872pubmed:meshHeadingpubmed-meshheading:12956872...lld:pubmed
pubmed-article:12956872pubmed:meshHeadingpubmed-meshheading:12956872...lld:pubmed
pubmed-article:12956872pubmed:meshHeadingpubmed-meshheading:12956872...lld:pubmed
pubmed-article:12956872pubmed:year2003lld:pubmed
pubmed-article:12956872pubmed:articleTitleBst-2/HM1.24 is a raft-associated apical membrane protein with an unusual topology.lld:pubmed
pubmed-article:12956872pubmed:affiliationDepartment of Biochemistry, University of Bristol, Bristol BS8 1TD, UK.lld:pubmed
pubmed-article:12956872pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:12956872pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
entrez-gene:378947entrezgene:pubmedpubmed-article:12956872lld:entrezgene
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12956872lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12956872lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12956872lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12956872lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12956872lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12956872lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12956872lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12956872lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12956872lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12956872lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12956872lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12956872lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12956872lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12956872lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12956872lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12956872lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12956872lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12956872lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12956872lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12956872lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12956872lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12956872lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12956872lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12956872lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12956872lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12956872lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12956872lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12956872lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12956872lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12956872lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12956872lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12956872lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12956872lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12956872lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12956872lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12956872lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12956872lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12956872lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12956872lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12956872lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12956872lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12956872lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12956872lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12956872lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12956872lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12956872lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12956872lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12956872lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12956872lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12956872lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12956872lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12956872lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12956872lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12956872lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12956872lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12956872lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12956872lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12956872lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12956872lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12956872lld:pubmed
More...