| pubmed-article:12950465 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12950465 | lifeskim:mentions | umls-concept:C0005854 | lld:lifeskim |
| pubmed-article:12950465 | lifeskim:mentions | umls-concept:C0005529 | lld:lifeskim |
| pubmed-article:12950465 | lifeskim:mentions | umls-concept:C0332120 | lld:lifeskim |
| pubmed-article:12950465 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:12950465 | pubmed:dateCreated | 2003-9-2 | lld:pubmed |
| pubmed-article:12950465 | pubmed:abstractText | Morphine-6-beta-d-glucuronide (M6G) is an active metabolite of morphine with high analgesic potency despite a low blood-brain barrier (BBB) permeability. The aim of the study was to elucidate its transport mechanism across the BBB. We first checked if M6G was effluxed by the P-glycoprotein (P-gp), as previously reported by others. Second, we investigated the role of anionic transporters like the multidrug resistance-associated protein mrp1 and the glucose transporter GLUT-1. The brain uptake of [14C]M6G was measured by the in situ brain perfusion technique in wild-type and deficient mice [mdr1a(-/-) and mrp1(-/-)], with and without probenecid, digoxin, PSC833 or d-glucose. No difference was found between P-gp and mrp1 competent and deficient mice. The brain uptake of [14C]M6G co-perfused with probenecid in wild-type mice was not significantly different from that found in group perfused with [14C]M6G alone. The co-perfusion of [14C]M6G with digoxin or PSC833 was responsible of a threefold decrease of its uptake in mdr1a competent and deficient mice, suggesting that another transporter than P-gp and sensitive to digoxin and PSC833, may be involved. The co-perfusion of [14C]M6G with d-glucose revealed a threefold decrease in M6G uptake. In conclusion, P-gp and mrp1 are not involved in the transport of M6G at the BBB level in contrast to GLUT-1 and a digoxin-sensitive transporter (probably oatp2), which can actively transport M6G but with a weak capacity. | lld:pubmed |
| pubmed-article:12950465 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12950465 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12950465 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12950465 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12950465 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12950465 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12950465 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12950465 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12950465 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12950465 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12950465 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12950465 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12950465 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12950465 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12950465 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12950465 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12950465 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12950465 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12950465 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12950465 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12950465 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:12950465 | pubmed:issn | 0022-3042 | lld:pubmed |
| pubmed-article:12950465 | pubmed:author | pubmed-author:TemsamaniJama... | lld:pubmed |
| pubmed-article:12950465 | pubmed:author | pubmed-author:ScherrmannJea... | lld:pubmed |
| pubmed-article:12950465 | pubmed:author | pubmed-author:CisterninoSal... | lld:pubmed |
| pubmed-article:12950465 | pubmed:author | pubmed-author:BourassetFanc... | lld:pubmed |
| pubmed-article:12950465 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12950465 | pubmed:volume | 86 | lld:pubmed |
| pubmed-article:12950465 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12950465 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12950465 | pubmed:pagination | 1564-7 | lld:pubmed |
| pubmed-article:12950465 | pubmed:dateRevised | 2005-11-17 | lld:pubmed |
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| pubmed-article:12950465 | pubmed:meshHeading | pubmed-meshheading:12950465... | lld:pubmed |
| pubmed-article:12950465 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12950465 | pubmed:articleTitle | Evidence for an active transport of morphine-6-beta-d-glucuronide but not P-glycoprotein-mediated at the blood-brain barrier. | lld:pubmed |
| pubmed-article:12950465 | pubmed:affiliation | INSERM U26, Hôpital Fernand Widal, Paris, France. Fanchon.Bourasset@fwidal.inserm.fr | lld:pubmed |
| pubmed-article:12950465 | pubmed:publicationType | Journal Article | lld:pubmed |
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