| pubmed-article:1294943 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1294943 | lifeskim:mentions | umls-concept:C0520484 | lld:lifeskim |
| pubmed-article:1294943 | lifeskim:mentions | umls-concept:C0725066 | lld:lifeskim |
| pubmed-article:1294943 | lifeskim:mentions | umls-concept:C0332185 | lld:lifeskim |
| pubmed-article:1294943 | pubmed:issue | 41 | lld:pubmed |
| pubmed-article:1294943 | pubmed:dateCreated | 1993-4-12 | lld:pubmed |
| pubmed-article:1294943 | pubmed:abstractText | Interest in xenotransplantation has dramatically increased in the past 4 years, focusing on the potential use as donors of distantly related animals such as pigs (discordant xenografts). The major barrier is hyperacute rejection. The mechanisms responsible for this rejection include: specific reaction of the recipient's natural antibodies with antigens in the donor's organ, direct activation of the recipient's complement system by endothelial cells in the donor's organ, and/or relative failure of complement inhibitory proteins in the donor's organ to impede activation of the recipient's complement system. In case of vascularized xenograft, the temporary depletion of anti-donor antibodies (anti-ABH or anti-HLA class I) from a graft recipient may allow the long term survival of the graft despite a possible return of the antibodies to the circulation. This phenomenon is called accommodation. The mechanisms involved could be: the endothelial cells in a graft develop a resistance to complement mediated injury; the antigens expressed on the blood vessels become modulated or changed; the natural antibody repertoire changes in such a way that there are fewer anti-donor antibodies. The accommodation phenomenon encourages the view that the barrier to xenotransplantation is not immutable. | lld:pubmed |
| pubmed-article:1294943 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1294943 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1294943 | pubmed:language | fre | lld:pubmed |
| pubmed-article:1294943 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1294943 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1294943 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1294943 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1294943 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1294943 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:1294943 | pubmed:issn | 0755-4982 | lld:pubmed |
| pubmed-article:1294943 | pubmed:author | pubmed-author:JeffreyLL | lld:pubmed |
| pubmed-article:1294943 | pubmed:author | pubmed-author:PlattM DMD | lld:pubmed |
| pubmed-article:1294943 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1294943 | pubmed:day | 2 | lld:pubmed |
| pubmed-article:1294943 | pubmed:volume | 21 | lld:pubmed |
| pubmed-article:1294943 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1294943 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1294943 | pubmed:pagination | 1932-8 | lld:pubmed |
| pubmed-article:1294943 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:1294943 | pubmed:meshHeading | pubmed-meshheading:1294943-... | lld:pubmed |
| pubmed-article:1294943 | pubmed:meshHeading | pubmed-meshheading:1294943-... | lld:pubmed |
| pubmed-article:1294943 | pubmed:meshHeading | pubmed-meshheading:1294943-... | lld:pubmed |
| pubmed-article:1294943 | pubmed:meshHeading | pubmed-meshheading:1294943-... | lld:pubmed |
| pubmed-article:1294943 | pubmed:meshHeading | pubmed-meshheading:1294943-... | lld:pubmed |
| pubmed-article:1294943 | pubmed:meshHeading | pubmed-meshheading:1294943-... | lld:pubmed |
| pubmed-article:1294943 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1294943 | pubmed:articleTitle | [Recent advances in xenotransplantation]. | lld:pubmed |
| pubmed-article:1294943 | pubmed:publicationType | Editorial | lld:pubmed |
| pubmed-article:1294943 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:1294943 | pubmed:publicationType | English Abstract | lld:pubmed |
| pubmed-article:1294943 | pubmed:publicationType | Review | lld:pubmed |
| pubmed-article:1294943 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
