| pubmed-article:12944920 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12944920 | lifeskim:mentions | umls-concept:C0086661 | lld:lifeskim |
| pubmed-article:12944920 | lifeskim:mentions | umls-concept:C0162638 | lld:lifeskim |
| pubmed-article:12944920 | lifeskim:mentions | umls-concept:C0596290 | lld:lifeskim |
| pubmed-article:12944920 | lifeskim:mentions | umls-concept:C0663446 | lld:lifeskim |
| pubmed-article:12944920 | lifeskim:mentions | umls-concept:C0020507 | lld:lifeskim |
| pubmed-article:12944920 | lifeskim:mentions | umls-concept:C0040649 | lld:lifeskim |
| pubmed-article:12944920 | pubmed:issue | 36 | lld:pubmed |
| pubmed-article:12944920 | pubmed:dateCreated | 2003-8-28 | lld:pubmed |
| pubmed-article:12944920 | pubmed:abstractText | c-Myc promotes cellular proliferation, sensitizes cells to apoptosis and prevents differentiation. It binds cyclin T1 structurally and functionally from the positive transcription elongation factor b (P-TEFb). The cyclin-dependent kinase 9 (Cdk9) in P-TEFb then phosporylates the C-terminal domain of RNA polymerase II, which is required for the transition from initiation to elongation of eukaryotic transcription. Inhibiting P-TEFb blocks the transcription of its target genes as well as cellular proliferation and apoptosis induced by c-Myc. | lld:pubmed |
| pubmed-article:12944920 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12944920 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12944920 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:12944920 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12944920 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:12944920 | pubmed:issn | 0950-9232 | lld:pubmed |
| pubmed-article:12944920 | pubmed:author | pubmed-author:PeterlinB... | lld:pubmed |
| pubmed-article:12944920 | pubmed:author | pubmed-author:SoucekLauraL | lld:pubmed |
| pubmed-article:12944920 | pubmed:author | pubmed-author:OkamotoTakash... | lld:pubmed |
| pubmed-article:12944920 | pubmed:author | pubmed-author:EvanGerardG | lld:pubmed |
| pubmed-article:12944920 | pubmed:author | pubmed-author:KanazawaSatos... | lld:pubmed |
| pubmed-article:12944920 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12944920 | pubmed:day | 28 | lld:pubmed |
| pubmed-article:12944920 | pubmed:volume | 22 | lld:pubmed |
| pubmed-article:12944920 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12944920 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12944920 | pubmed:pagination | 5707-11 | lld:pubmed |
| pubmed-article:12944920 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:12944920 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12944920 | pubmed:articleTitle | c-Myc recruits P-TEFb for transcription, cellular proliferation and apoptosis. | lld:pubmed |
| pubmed-article:12944920 | pubmed:affiliation | Departments of Medicine, Microbiology and Immunology, Rosalind Russell Medical Research Center, University of California, San Francisco, CA 94143-0703, USA. | lld:pubmed |
| pubmed-article:12944920 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12944920 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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