| pubmed-article:12944369 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12944369 | lifeskim:mentions | umls-concept:C0026239 | lld:lifeskim |
| pubmed-article:12944369 | lifeskim:mentions | umls-concept:C1882726 | lld:lifeskim |
| pubmed-article:12944369 | lifeskim:mentions | umls-concept:C0010592 | lld:lifeskim |
| pubmed-article:12944369 | lifeskim:mentions | umls-concept:C0010749 | lld:lifeskim |
| pubmed-article:12944369 | lifeskim:mentions | umls-concept:C0022023 | lld:lifeskim |
| pubmed-article:12944369 | lifeskim:mentions | umls-concept:C0037125 | lld:lifeskim |
| pubmed-article:12944369 | lifeskim:mentions | umls-concept:C1705165 | lld:lifeskim |
| pubmed-article:12944369 | lifeskim:mentions | umls-concept:C0031164 | lld:lifeskim |
| pubmed-article:12944369 | lifeskim:mentions | umls-concept:C0030685 | lld:lifeskim |
| pubmed-article:12944369 | lifeskim:mentions | umls-concept:C0680255 | lld:lifeskim |
| pubmed-article:12944369 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:12944369 | lifeskim:mentions | umls-concept:C0391871 | lld:lifeskim |
| pubmed-article:12944369 | lifeskim:mentions | umls-concept:C1283071 | lld:lifeskim |
| pubmed-article:12944369 | lifeskim:mentions | umls-concept:C1963578 | lld:lifeskim |
| pubmed-article:12944369 | lifeskim:mentions | umls-concept:C2700061 | lld:lifeskim |
| pubmed-article:12944369 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:12944369 | pubmed:dateCreated | 2003-8-28 | lld:pubmed |
| pubmed-article:12944369 | pubmed:abstractText | Various reagents are known to open the mitochondrial permeability pore (PTP) and induce a permeability transition (PT), releasing apoptogenic proteins from the intermembrane space and triggering apoptosis. In this study, we examined the effect of Ag(+), a known cytotoxic sulfhydryl-reactive heavy metal, on isolated rat liver mitochondria. The following results were obtained: (1) Upon addition, Ag(+) instantly induced mitochondrial swelling and acceleration of respiration. (2) Cyclosporine A, a specific inhibitor of classical PT, was ineffective against the effect of Ag(+), indicating that silver ions induced non-classic PT. (3) Sulfhydryl reagents such as reduced glutathione completely inhibited the effects of Ag(+) on the mitochondria. (4) Experimental results using polyethylene glycol indicated that Ag(+) induced opening of a pore in the inner mitochondrial membrane, which could be PTP of another open state or a distinct pore. (5) Electron microscopic analysis of mitochondria treated with Ag(+) showed a novel mitochondrial configuration that was apparently different from that of normal mitochondria or Ca(2+)-treated mitochondria. (6) Ag(+) also induced the release of apoptogenic cytochrome c in a CsA-insensitive but GSH-sensitive manner. These results suggest that Ag(+) promotes a nonclassical permeability increase in the mitochondrial inner membrane that is clearly distinguishable from the classical PT and releases apoptogenic cytochrome c in a classical PT-independent manner. | lld:pubmed |
| pubmed-article:12944369 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12944369 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12944369 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12944369 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12944369 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12944369 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12944369 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12944369 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12944369 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12944369 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12944369 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12944369 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:12944369 | pubmed:issn | 0021-924X | lld:pubmed |
| pubmed-article:12944369 | pubmed:author | pubmed-author:ShinoharaYasu... | lld:pubmed |
| pubmed-article:12944369 | pubmed:author | pubmed-author:TeradaHiroshi... | lld:pubmed |
| pubmed-article:12944369 | pubmed:author | pubmed-author:AlmoftiMohama... | lld:pubmed |
| pubmed-article:12944369 | pubmed:author | pubmed-author:YamashitaKiku... | lld:pubmed |
| pubmed-article:12944369 | pubmed:author | pubmed-author:IchikawaTomok... | lld:pubmed |
| pubmed-article:12944369 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12944369 | pubmed:volume | 134 | lld:pubmed |
| pubmed-article:12944369 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12944369 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12944369 | pubmed:pagination | 43-9 | lld:pubmed |
| pubmed-article:12944369 | pubmed:dateRevised | 2007-12-19 | lld:pubmed |
| pubmed-article:12944369 | pubmed:meshHeading | pubmed-meshheading:12944369... | lld:pubmed |
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| pubmed-article:12944369 | pubmed:meshHeading | pubmed-meshheading:12944369... | lld:pubmed |
| pubmed-article:12944369 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12944369 | pubmed:articleTitle | Silver ion induces a cyclosporine a-insensitive permeability transition in rat liver mitochondria and release of apoptogenic cytochrome C. | lld:pubmed |
| pubmed-article:12944369 | pubmed:affiliation | Faculty of Pharmaceutical Sciences, The University of Tokushima, Shomachi 1, Tokushima 770-8505. radwanjp@yahoo.com | lld:pubmed |
| pubmed-article:12944369 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12944369 | lld:pubmed |
