| pubmed-article:12941813 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12941813 | lifeskim:mentions | umls-concept:C0374711 | lld:lifeskim |
| pubmed-article:12941813 | lifeskim:mentions | umls-concept:C0043240 | lld:lifeskim |
| pubmed-article:12941813 | lifeskim:mentions | umls-concept:C0012860 | lld:lifeskim |
| pubmed-article:12941813 | lifeskim:mentions | umls-concept:C0005516 | lld:lifeskim |
| pubmed-article:12941813 | lifeskim:mentions | umls-concept:C2674950 | lld:lifeskim |
| pubmed-article:12941813 | lifeskim:mentions | umls-concept:C1514468 | lld:lifeskim |
| pubmed-article:12941813 | lifeskim:mentions | umls-concept:C0311404 | lld:lifeskim |
| pubmed-article:12941813 | lifeskim:mentions | umls-concept:C1705181 | lld:lifeskim |
| pubmed-article:12941813 | pubmed:issue | 16 | lld:pubmed |
| pubmed-article:12941813 | pubmed:dateCreated | 2003-8-27 | lld:pubmed |
| pubmed-article:12941813 | pubmed:abstractText | The broad spectrum of oxidative DNA damage biomarkers [urinary excretion of 8-hydroxy-2'-deoxyguanosine (8-OH-dGuo) and 8-hydroxyguanine (8-OH-Gua)] and the level of oxidative DNA damage and repair in leukocytes DNA were analyzed in three groups of subjects: (a) lung cancer patients [all smokers (n = 51)]; (b) healthy smokers with comparable smoking status (n = 26); and (c) healthy nonsmokers (n = 38). The mean level of 8-OH-Gua in urine samples of 38 healthy nonsmokers reached a value of 1.783 +/- 0.785 nmol/day/kg. This level was significantly lower than that in the urine of the two smoker groups (cancer patients and healthy smokers), in whom the levels reached values of 2.319 +/- 1.271 and 2.824 +/- 0.892 nmol/day/kg, respectively. Urinary excretion of 8-OH-dGuo was similar in all groups of subjects. The level of 8-OH-dGuo in DNA isolated from leukocytes of cancer patients was significantly higher than that in DNA isolated from the group of healthy smokers and nonsmokers (9.44 +/- 4.77 versus 7.20 +/- 2.83 and 5.88 +/- 2.47 molecules/10(6) deoxyguanosine, respectively). Repair activity of 8-OH-Gua, as estimated by the nicking assay, was significantly higher in blood leukocytes of healthy volunteers (44.6 +/- 20.21 and 37.54 +/- 13.43 pmol/h/mg protein for smokers and nonsmokers, respectively) than in the leukocytes of lung cancer patients (24.56 +/- 11.28 pmol/h/mg protein). Because oxidative DNA insult represented by urinary excretion of oxidative DNA lesions was similar in both groups of subjects with similar smoking status, it appears likely that a higher rate of generation of oxidative damage in cellular DNA of lung cancer patients is a result of deficiency of the repair mechanism(s) in this group. | lld:pubmed |
| pubmed-article:12941813 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12941813 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12941813 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:12941813 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12941813 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:12941813 | pubmed:issn | 0008-5472 | lld:pubmed |
| pubmed-article:12941813 | pubmed:author | pubmed-author:GackowskiDani... | lld:pubmed |
| pubmed-article:12941813 | pubmed:author | pubmed-author:OlinskiRyszar... | lld:pubmed |
| pubmed-article:12941813 | pubmed:author | pubmed-author:RozalskiRafal... | lld:pubmed |
| pubmed-article:12941813 | pubmed:author | pubmed-author:TudekBarbaraB | lld:pubmed |
| pubmed-article:12941813 | pubmed:author | pubmed-author:PaciorekTomas... | lld:pubmed |
| pubmed-article:12941813 | pubmed:author | pubmed-author:SpeinaElzbiet... | lld:pubmed |
| pubmed-article:12941813 | pubmed:author | pubmed-author:KowalewskiJan... | lld:pubmed |
| pubmed-article:12941813 | pubmed:author | pubmed-author:ZielinskaMaja... | lld:pubmed |
| pubmed-article:12941813 | pubmed:author | pubmed-author:SiomekAgniesz... | lld:pubmed |
| pubmed-article:12941813 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12941813 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:12941813 | pubmed:volume | 63 | lld:pubmed |
| pubmed-article:12941813 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12941813 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12941813 | pubmed:pagination | 4899-902 | lld:pubmed |
| pubmed-article:12941813 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:12941813 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12941813 | pubmed:articleTitle | Products of oxidative DNA damage and repair as possible biomarkers of susceptibility to lung cancer. | lld:pubmed |
| pubmed-article:12941813 | pubmed:affiliation | Department of Clinical Biochemistry, The L. Rydygier Medical University, 85-092 Bydgoszcz, Poland. | lld:pubmed |
| pubmed-article:12941813 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12941813 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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