| pubmed-article:12941324 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12941324 | lifeskim:mentions | umls-concept:C0022173 | lld:lifeskim |
| pubmed-article:12941324 | lifeskim:mentions | umls-concept:C0033634 | lld:lifeskim |
| pubmed-article:12941324 | lifeskim:mentions | umls-concept:C0220781 | lld:lifeskim |
| pubmed-article:12941324 | lifeskim:mentions | umls-concept:C1511644 | lld:lifeskim |
| pubmed-article:12941324 | lifeskim:mentions | umls-concept:C1167622 | lld:lifeskim |
| pubmed-article:12941324 | lifeskim:mentions | umls-concept:C1883254 | lld:lifeskim |
| pubmed-article:12941324 | pubmed:issue | 18 | lld:pubmed |
| pubmed-article:12941324 | pubmed:dateCreated | 2003-8-27 | lld:pubmed |
| pubmed-article:12941324 | pubmed:abstractText | Benzolactone-V8 (4) is a lactone analogue of the artificial tumor promoter benzolactam-V8 (1). To investigate the effect of hydrophobic substituents at positions 7 and 15 of 4 on binding selectivity for protein kinase C (PKC) isozymes, 7- and 15-decylbenzolactone-V8 (7, 8) were synthesized and their binding affinities for synthetic PKC isozyme C1 peptides were examined. Compound 8 showed moderate selectivity for novel PKC isozymes similar to 9-decylbenzolactone-V8 (5), while 7 was less selective. Compounds 7 and 8 showed no significant selectivity among novel PKC isozymes unlike 8-decylbenzolactone-V8 (6). These results indicate that the introduction of a hydrophobic substituent at position 8 of 4 is most effective in the development of PKC epsilon- and PKCeta-selective binders. | lld:pubmed |
| pubmed-article:12941324 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12941324 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12941324 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12941324 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12941324 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12941324 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12941324 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12941324 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12941324 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12941324 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:12941324 | pubmed:issn | 0960-894X | lld:pubmed |
| pubmed-article:12941324 | pubmed:author | pubmed-author:OhigashiHajim... | lld:pubmed |
| pubmed-article:12941324 | pubmed:author | pubmed-author:IrieKazuhiroK | lld:pubmed |
| pubmed-article:12941324 | pubmed:author | pubmed-author:NakagawaYuY | lld:pubmed |
| pubmed-article:12941324 | pubmed:author | pubmed-author:YamanakaNobuh... | lld:pubmed |
| pubmed-article:12941324 | pubmed:author | pubmed-author:TsudaKen-ichi... | lld:pubmed |
| pubmed-article:12941324 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12941324 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:12941324 | pubmed:volume | 13 | lld:pubmed |
| pubmed-article:12941324 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12941324 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12941324 | pubmed:pagination | 3015-9 | lld:pubmed |
| pubmed-article:12941324 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
| pubmed-article:12941324 | pubmed:meshHeading | pubmed-meshheading:12941324... | lld:pubmed |
| pubmed-article:12941324 | pubmed:meshHeading | pubmed-meshheading:12941324... | lld:pubmed |
| pubmed-article:12941324 | pubmed:meshHeading | pubmed-meshheading:12941324... | lld:pubmed |
| pubmed-article:12941324 | pubmed:meshHeading | pubmed-meshheading:12941324... | lld:pubmed |
| pubmed-article:12941324 | pubmed:meshHeading | pubmed-meshheading:12941324... | lld:pubmed |
| pubmed-article:12941324 | pubmed:meshHeading | pubmed-meshheading:12941324... | lld:pubmed |
| pubmed-article:12941324 | pubmed:meshHeading | pubmed-meshheading:12941324... | lld:pubmed |
| pubmed-article:12941324 | pubmed:meshHeading | pubmed-meshheading:12941324... | lld:pubmed |
| pubmed-article:12941324 | pubmed:meshHeading | pubmed-meshheading:12941324... | lld:pubmed |
| pubmed-article:12941324 | pubmed:meshHeading | pubmed-meshheading:12941324... | lld:pubmed |
| pubmed-article:12941324 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12941324 | pubmed:articleTitle | Synthesis and binding selectivity of 7- and 15-decylbenzolactone-V8 for the C1 domains of protein kinase C isozymes. | lld:pubmed |
| pubmed-article:12941324 | pubmed:affiliation | Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Kyoto 606-8502, Japan. | lld:pubmed |
| pubmed-article:12941324 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12941324 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:12941324 | lld:chembl |
