| pubmed-article:12936985 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12936985 | lifeskim:mentions | umls-concept:C0205474 | lld:lifeskim |
| pubmed-article:12936985 | lifeskim:mentions | umls-concept:C0033809 | lld:lifeskim |
| pubmed-article:12936985 | lifeskim:mentions | umls-concept:C0597979 | lld:lifeskim |
| pubmed-article:12936985 | lifeskim:mentions | umls-concept:C1521991 | lld:lifeskim |
| pubmed-article:12936985 | lifeskim:mentions | umls-concept:C0456387 | lld:lifeskim |
| pubmed-article:12936985 | lifeskim:mentions | umls-concept:C1880022 | lld:lifeskim |
| pubmed-article:12936985 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:12936985 | pubmed:dateCreated | 2003-8-25 | lld:pubmed |
| pubmed-article:12936985 | pubmed:abstractText | As part of the CANCER Antimicrobial Surveillance Program in North America, a clinical strain of Pseudomonas aeruginosa, strain 07-406, isolated in Texas was found to be resistant to all antimicrobials except polymyxin B. Genetic analysis of this isolate identified two unique extended-spectrum beta-lactamase genes. One, bla(VIM-7), encoded a metallo-beta-lactamase (unpublished data), and the other, bla(OXA-45), described here, encoded a class D extended-spectrum beta-lactamase. bla(OXA-45) was isolated on a Sau3A1 genomic fragment of 1.8 kb and encodes a protein of 264 amino acids with the highest identities to OXA-18 (65.9%), OXA-9 (42.8%), OXA-22 (40.2%), OXA-12 (38.6%), and OXA-29 (35.2%) but weak identities with other class D beta-lactamases. bla(OXA-45) was found to be harbored on a 24-kb plasmid in a region that displays high identities with a section of the 43-kb genomic island of Salmonella enterica serovar Typhimurium DT104. Biochemically OXA-45 is most similar to OXA-18 in its substrate profile and inhibition by clavulanic acid and is a member of the 2d' class of beta-lactamases. | lld:pubmed |
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| pubmed-article:12936985 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12936985 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12936985 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:12936985 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12936985 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:12936985 | pubmed:issn | 0066-4804 | lld:pubmed |
| pubmed-article:12936985 | pubmed:author | pubmed-author:WalshTimothy... | lld:pubmed |
| pubmed-article:12936985 | pubmed:author | pubmed-author:JonesRonald... | lld:pubmed |
| pubmed-article:12936985 | pubmed:author | pubmed-author:RolstonKennet... | lld:pubmed |
| pubmed-article:12936985 | pubmed:author | pubmed-author:TolemanMark... | lld:pubmed |
| pubmed-article:12936985 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12936985 | pubmed:volume | 47 | lld:pubmed |
| pubmed-article:12936985 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12936985 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12936985 | pubmed:pagination | 2859-63 | lld:pubmed |
| pubmed-article:12936985 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:12936985 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12936985 | pubmed:articleTitle | Molecular and biochemical characterization of OXA-45, an extended-spectrum class 2d' beta-lactamase in Pseudomonas aeruginosa. | lld:pubmed |
| pubmed-article:12936985 | pubmed:affiliation | Department of Pathology and Microbiology, University of Bristol, Bristol BS8 1TD, United Kingdom. Mark.Toleman@bristol.ac.uk | lld:pubmed |
| pubmed-article:12936985 | pubmed:publicationType | Journal Article | lld:pubmed |
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