| pubmed-article:12933588 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12933588 | lifeskim:mentions | umls-concept:C0596993 | lld:lifeskim |
| pubmed-article:12933588 | lifeskim:mentions | umls-concept:C0082978 | lld:lifeskim |
| pubmed-article:12933588 | lifeskim:mentions | umls-concept:C1537422 | lld:lifeskim |
| pubmed-article:12933588 | lifeskim:mentions | umls-concept:C1752930 | lld:lifeskim |
| pubmed-article:12933588 | pubmed:issue | 13 | lld:pubmed |
| pubmed-article:12933588 | pubmed:dateCreated | 2003-12-5 | lld:pubmed |
| pubmed-article:12933588 | pubmed:abstractText | Interferon consensus sequence binding protein/interferon regulatory factor 8 (ICSBP/IRF-8) is a transcription factor that controls myeloid cell development. ICSBP-/- mice develop a chronic myelogenous leukemia (CML)-like syndrome. Several observations on patients and mouse models have implicated ICSBP in the pathogenesis of CML. In this paper, we investigated whether ICSBP modulates the growth-promoting activity of Bcr/Abl, the causal oncoprotein for CML. When transformed with p210 Bcr/Abl, ICSBP-/- myeloid progenitor cells lost growth factor dependence and grew in the absence of granulocyte-macrophage colony-stimulating factor. When ICSBP was ectopically expressed, Bcr/Abl-transformed cells underwent complete growth arrest and differentiated into mature, functional macrophages without inhibiting the kinase activity of Bcr/Abl. Providing a mechanistic basis for the growth arrest, ICSBP markedly repressed c-Myc messenger RNA (mRNA)-expression, a downstream target of Bcr/Abl. A further analysis with the ICSBP/estrogen receptor chimera showed that ICSBP repression of c-Myc is indirect and is mediated by another gene(s). We identified Blimp-1 and METS/PE1, potent c-Myc repressors, as direct targets of ICSBP activated in these cells. Consistent with this, ectopic Blimp-1 repressed c-Myc expression and inhibited cell growth. These results indicate that ICSBP inhibits growth of Bcr/Abl-transformed myeloid progenitor cells by activating several genes that interfere with the c-Myc pathway. | lld:pubmed |
| pubmed-article:12933588 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12933588 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12933588 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:12933588 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12933588 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:12933588 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12933588 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12933588 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:12933588 | pubmed:issn | 0006-4971 | lld:pubmed |
| pubmed-article:12933588 | pubmed:author | pubmed-author:OzatoKeikoK | lld:pubmed |
| pubmed-article:12933588 | pubmed:author | pubmed-author:TamuraTomohik... | lld:pubmed |
| pubmed-article:12933588 | pubmed:author | pubmed-author:CalameKathryn... | lld:pubmed |
| pubmed-article:12933588 | pubmed:author | pubmed-author:TsujimuraHide... | lld:pubmed |
| pubmed-article:12933588 | pubmed:author | pubmed-author:TunyaplinChai... | lld:pubmed |
| pubmed-article:12933588 | pubmed:author | pubmed-author:KongHee... | lld:pubmed |
| pubmed-article:12933588 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12933588 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:12933588 | pubmed:volume | 102 | lld:pubmed |
| pubmed-article:12933588 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12933588 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12933588 | pubmed:pagination | 4547-54 | lld:pubmed |
| pubmed-article:12933588 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:12933588 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12933588 | pubmed:articleTitle | ICSBP/IRF-8 inhibits mitogenic activity of p210 Bcr/Abl in differentiating myeloid progenitor cells. | lld:pubmed |
| pubmed-article:12933588 | pubmed:affiliation | Bldg 6, Rm 2A01, Laboratory of Molecular Growth Regulation, National Institute of Child Health and Human Development, National Institutes of Health, 6 Center Dr MSC 2753, Bethesda, MD 20892-2753, USA. | lld:pubmed |
| pubmed-article:12933588 | pubmed:publicationType | Journal Article | lld:pubmed |
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