| pubmed-article:12928584 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12928584 | lifeskim:mentions | umls-concept:C0006104 | lld:lifeskim |
| pubmed-article:12928584 | lifeskim:mentions | umls-concept:C0031327 | lld:lifeskim |
| pubmed-article:12928584 | lifeskim:mentions | umls-concept:C0022180 | lld:lifeskim |
| pubmed-article:12928584 | lifeskim:mentions | umls-concept:C0243144 | lld:lifeskim |
| pubmed-article:12928584 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:12928584 | pubmed:dateCreated | 2003-8-20 | lld:pubmed |
| pubmed-article:12928584 | pubmed:abstractText | We studied the effect of the inspired isoflurane concentration (C(I)iso) on the pharmacokinetics of isoflurane uptake in the brain by comparing the isoflurane concentration in internal jugular-bulb blood (Jiso) with that in arterial blood (Aiso), and analyzed this by gas chromatography. Sixteen patients (aged 43-76 years) undergoing colorectal surgery were enrolled, and anesthesia was maintained with a constant C(I)iso of either 1% (group 1, n = 8) or 2% (group 2, n = 8) during the 1st hour of isoflurane anesthesia. Under constant volume-controlled ventilation, we measured the C(I)iso and the end-tidal isoflurane concentration (C(E)iso) at the mouthpiece by infrared analysis. Our results demonstrate that it takes 40 min for the brain tissue concentration to equal Aiso for 1% C(I)iso, and 50 min for 2% C(I)iso. The Aiso (and/or Jiso) for 2% C(I)iso was approximately double when compared to that for 1% C(I)iso. Except during the initial wash-in period of the functional residual capacity in the first 3 min, the differences between C(I)iso and C(E)iso revealed that the body uptake of isoflurane for 2% C(I)iso was twice that for 1% C(I)iso. These results demonstrate that the pharmacokinetics of isoflurane uptake in the brain is time-dependent for Jiso to equal Aiso, and the midpoint between Aiso and Jiso (likely representing the isoflurane concentration in brain tissue) was dependent on C(I)iso. | lld:pubmed |
| pubmed-article:12928584 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12928584 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12928584 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12928584 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12928584 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12928584 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12928584 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:12928584 | pubmed:issn | 0031-7012 | lld:pubmed |
| pubmed-article:12928584 | pubmed:author | pubmed-author:HoShung-TaiST | lld:pubmed |
| pubmed-article:12928584 | pubmed:author | pubmed-author:WongChih-Shun... | lld:pubmed |
| pubmed-article:12928584 | pubmed:author | pubmed-author:WangJhi-Joung... | lld:pubmed |
| pubmed-article:12928584 | pubmed:author | pubmed-author:ChangSun-Yran... | lld:pubmed |
| pubmed-article:12928584 | pubmed:author | pubmed-author:LinChung-Yuan... | lld:pubmed |
| pubmed-article:12928584 | pubmed:author | pubmed-author:LuChih-Cherng... | lld:pubmed |
| pubmed-article:12928584 | pubmed:author | pubmed-author:HuOliver... | lld:pubmed |
| pubmed-article:12928584 | pubmed:copyrightInfo | Copyright 2003 S. Karger AG, Basel | lld:pubmed |
| pubmed-article:12928584 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12928584 | pubmed:volume | 69 | lld:pubmed |
| pubmed-article:12928584 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12928584 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12928584 | pubmed:pagination | 102-7 | lld:pubmed |
| pubmed-article:12928584 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:12928584 | pubmed:meshHeading | pubmed-meshheading:12928584... | lld:pubmed |
| pubmed-article:12928584 | pubmed:meshHeading | pubmed-meshheading:12928584... | lld:pubmed |
| pubmed-article:12928584 | pubmed:meshHeading | pubmed-meshheading:12928584... | lld:pubmed |
| pubmed-article:12928584 | pubmed:meshHeading | pubmed-meshheading:12928584... | lld:pubmed |
| pubmed-article:12928584 | pubmed:meshHeading | pubmed-meshheading:12928584... | lld:pubmed |
| pubmed-article:12928584 | pubmed:meshHeading | pubmed-meshheading:12928584... | lld:pubmed |
| pubmed-article:12928584 | pubmed:meshHeading | pubmed-meshheading:12928584... | lld:pubmed |
| pubmed-article:12928584 | pubmed:meshHeading | pubmed-meshheading:12928584... | lld:pubmed |
| pubmed-article:12928584 | pubmed:meshHeading | pubmed-meshheading:12928584... | lld:pubmed |
| pubmed-article:12928584 | pubmed:meshHeading | pubmed-meshheading:12928584... | lld:pubmed |
| pubmed-article:12928584 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12928584 | pubmed:articleTitle | Pharmacokinetics of isoflurane: uptake in the brain. | lld:pubmed |
| pubmed-article:12928584 | pubmed:affiliation | Department of Anesthesiology, Tri-Service General Hospital, National Defense Medical Center, No. 161, Section 6 Minchuan E. Road, Taipei, Taiwan. | lld:pubmed |
| pubmed-article:12928584 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12928584 | pubmed:publicationType | Clinical Trial | lld:pubmed |
| pubmed-article:12928584 | pubmed:publicationType | Controlled Clinical Trial | lld:pubmed |
| pubmed-article:12928584 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
