| pubmed-article:12921928 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12921928 | lifeskim:mentions | umls-concept:C0008976 | lld:lifeskim |
| pubmed-article:12921928 | lifeskim:mentions | umls-concept:C0032863 | lld:lifeskim |
| pubmed-article:12921928 | lifeskim:mentions | umls-concept:C0002783 | lld:lifeskim |
| pubmed-article:12921928 | lifeskim:mentions | umls-concept:C0936012 | lld:lifeskim |
| pubmed-article:12921928 | lifeskim:mentions | umls-concept:C0086322 | lld:lifeskim |
| pubmed-article:12921928 | lifeskim:mentions | umls-concept:C1701901 | lld:lifeskim |
| pubmed-article:12921928 | lifeskim:mentions | umls-concept:C1705294 | lld:lifeskim |
| pubmed-article:12921928 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:12921928 | pubmed:dateCreated | 2003-8-18 | lld:pubmed |
| pubmed-article:12921928 | pubmed:abstractText | Early stopping of a clinical trial is well accepted when there is enough evidence for a significant effect. However, during the course of a trial, there can be reasons to consider early termination for "futility." In epidemiologic studies, costly or destructive laboratory tests or slow case accrual can make it desirable to stop a study early for reasons of efficiency. Estimation of the conditional power (CP) is proposed as a decision tool to stop a study early or to continue it. We consider the disadvantages of this method. We propose (group) sequential continuation of the trial or study as a less arbitrary strategy. We re-analyzed two data sets from the literature to illustrate the advantages of a sequential approach. We conclude that (group) sequential analyses have several advantages over CP. More studies should consider a sequential design and analysis to enable early stopping when enough evidence has accumulated to conclude a lack of the expected effect. Such a strategy can save valuable resources for more promising hypotheses. | lld:pubmed |
| pubmed-article:12921928 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12921928 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12921928 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12921928 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12921928 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12921928 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:12921928 | pubmed:issn | 0895-4356 | lld:pubmed |
| pubmed-article:12921928 | pubmed:author | pubmed-author:van der... | lld:pubmed |
| pubmed-article:12921928 | pubmed:author | pubmed-author:van... | lld:pubmed |
| pubmed-article:12921928 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12921928 | pubmed:volume | 56 | lld:pubmed |
| pubmed-article:12921928 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12921928 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12921928 | pubmed:pagination | 610-7 | lld:pubmed |
| pubmed-article:12921928 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
| pubmed-article:12921928 | pubmed:meshHeading | pubmed-meshheading:12921928... | lld:pubmed |
| pubmed-article:12921928 | pubmed:meshHeading | pubmed-meshheading:12921928... | lld:pubmed |
| pubmed-article:12921928 | pubmed:meshHeading | pubmed-meshheading:12921928... | lld:pubmed |
| pubmed-article:12921928 | pubmed:meshHeading | pubmed-meshheading:12921928... | lld:pubmed |
| pubmed-article:12921928 | pubmed:meshHeading | pubmed-meshheading:12921928... | lld:pubmed |
| pubmed-article:12921928 | pubmed:meshHeading | pubmed-meshheading:12921928... | lld:pubmed |
| pubmed-article:12921928 | pubmed:meshHeading | pubmed-meshheading:12921928... | lld:pubmed |
| pubmed-article:12921928 | pubmed:meshHeading | pubmed-meshheading:12921928... | lld:pubmed |
| pubmed-article:12921928 | pubmed:meshHeading | pubmed-meshheading:12921928... | lld:pubmed |
| pubmed-article:12921928 | pubmed:meshHeading | pubmed-meshheading:12921928... | lld:pubmed |
| pubmed-article:12921928 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12921928 | pubmed:articleTitle | Early stopping in clinical trials and epidemiologic studies for "futility": conditional power versus sequential analysis. | lld:pubmed |
| pubmed-article:12921928 | pubmed:affiliation | Centre for Biostatistics, Utrecht University, Centrumgebouw Noord C122, Padualaan 14, 3584 CH Utrecht, The Netherlands. i.vandertweel@bio.uu.nl | lld:pubmed |
| pubmed-article:12921928 | pubmed:publicationType | Journal Article | lld:pubmed |
