| pubmed-article:12910437 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12910437 | lifeskim:mentions | umls-concept:C0014059 | lld:lifeskim |
| pubmed-article:12910437 | lifeskim:mentions | umls-concept:C0008059 | lld:lifeskim |
| pubmed-article:12910437 | lifeskim:mentions | umls-concept:C0021760 | lld:lifeskim |
| pubmed-article:12910437 | lifeskim:mentions | umls-concept:C0220781 | lld:lifeskim |
| pubmed-article:12910437 | lifeskim:mentions | umls-concept:C1883254 | lld:lifeskim |
| pubmed-article:12910437 | lifeskim:mentions | umls-concept:C0133821 | lld:lifeskim |
| pubmed-article:12910437 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:12910437 | pubmed:dateCreated | 2003-8-11 | lld:pubmed |
| pubmed-article:12910437 | pubmed:abstractText | Interleukin-6 (IL-6) has a number of roles including recruitment of T lymphocytes and differentiation of B lymphocytes into IgG-secreting plasma cells. Furthermore, IL-6 is a neuropoietic cytokine with effects on neuronal differentiation, function and survival. We studied IL-6 concentrations in children with acute disseminated encephalomyelitis (ADEM; n = 14), and compared the values with those obtained from control patients with other inflammatory (OIND; n = 13) and non-inflammatory (NIND; n = 10) neurological disorders. Patients with ADEM had a significantly increased CSF IL-6 concentration compared with both OIND and NIND groups ( P < 0.01). Serum IL-6 was also increased in the ADEM group compared with the OIND group ( P < 0.05). CSF: serum IL-6 ratios were significantly increased in the ADEM group compared with the NIND group ( P < 0.05), suggesting an intrathecal production of IL-6 rather than its passive transfer across the blood-brain barrier alone. In ADEM, there was a significant correlation between an increased CSF IL-6 and an identical pattern of oligoclonal IgG synthesis in both serum and CSF ( P < 0.05). These results would suggest a role for IL-6 in the pathology of ADEM, and a possible direct link between an increased IL-6 and a proliferation of B lymphocytes with consequent IgG production. | lld:pubmed |
| pubmed-article:12910437 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12910437 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12910437 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12910437 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12910437 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12910437 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12910437 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12910437 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:12910437 | pubmed:issn | 0174-304X | lld:pubmed |
| pubmed-article:12910437 | pubmed:author | pubmed-author:DaleR CRC | lld:pubmed |
| pubmed-article:12910437 | pubmed:author | pubmed-author:MorovatAA | lld:pubmed |
| pubmed-article:12910437 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12910437 | pubmed:volume | 34 | lld:pubmed |
| pubmed-article:12910437 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12910437 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12910437 | pubmed:pagination | 141-5 | lld:pubmed |
| pubmed-article:12910437 | pubmed:dateRevised | 2008-1-16 | lld:pubmed |
| pubmed-article:12910437 | pubmed:meshHeading | pubmed-meshheading:12910437... | lld:pubmed |
| pubmed-article:12910437 | pubmed:meshHeading | pubmed-meshheading:12910437... | lld:pubmed |
| pubmed-article:12910437 | pubmed:meshHeading | pubmed-meshheading:12910437... | lld:pubmed |
| pubmed-article:12910437 | pubmed:meshHeading | pubmed-meshheading:12910437... | lld:pubmed |
| pubmed-article:12910437 | pubmed:meshHeading | pubmed-meshheading:12910437... | lld:pubmed |
| pubmed-article:12910437 | pubmed:meshHeading | pubmed-meshheading:12910437... | lld:pubmed |
| pubmed-article:12910437 | pubmed:meshHeading | pubmed-meshheading:12910437... | lld:pubmed |
| pubmed-article:12910437 | pubmed:meshHeading | pubmed-meshheading:12910437... | lld:pubmed |
| pubmed-article:12910437 | pubmed:meshHeading | pubmed-meshheading:12910437... | lld:pubmed |
| pubmed-article:12910437 | pubmed:meshHeading | pubmed-meshheading:12910437... | lld:pubmed |
| pubmed-article:12910437 | pubmed:meshHeading | pubmed-meshheading:12910437... | lld:pubmed |
| pubmed-article:12910437 | pubmed:meshHeading | pubmed-meshheading:12910437... | lld:pubmed |
| pubmed-article:12910437 | pubmed:meshHeading | pubmed-meshheading:12910437... | lld:pubmed |
| pubmed-article:12910437 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12910437 | pubmed:articleTitle | Interleukin-6 and oligoclonal IgG synthesis in children with acute disseminated encephalomyelitis. | lld:pubmed |
| pubmed-article:12910437 | pubmed:affiliation | Neurosciences Unit, Institute of Child health and Great Ormond Street Hospital NHS Trust, London, UK. R.Dale@ion.ucl.ac.uk | lld:pubmed |
| pubmed-article:12910437 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12910437 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
