| pubmed-article:12909723 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12909723 | lifeskim:mentions | umls-concept:C0162638 | lld:lifeskim |
| pubmed-article:12909723 | lifeskim:mentions | umls-concept:C0334227 | lld:lifeskim |
| pubmed-article:12909723 | lifeskim:mentions | umls-concept:C0001128 | lld:lifeskim |
| pubmed-article:12909723 | lifeskim:mentions | umls-concept:C1527249 | lld:lifeskim |
| pubmed-article:12909723 | lifeskim:mentions | umls-concept:C1514468 | lld:lifeskim |
| pubmed-article:12909723 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:12909723 | pubmed:issue | 17 | lld:pubmed |
| pubmed-article:12909723 | pubmed:dateCreated | 2003-8-20 | lld:pubmed |
| pubmed-article:12909723 | pubmed:abstractText | Diminished apoptosis, a critical event in tumorigenesis, is linked to down-regulated 15-lipoxygenase-1 (15-LOX-1) expression in colorectal cancer cells. 13-S-hydroxyoctadecadienoic acid (13-S-HODE), which is the primary product of 15-LOX-1 metabolism of linoleic acid, restores apoptosis. Nonsteroidal antiinflammatory drugs (NSAIDs) transcriptionally up-regulate 15-LOX-1 expression to induce apoptosis. Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors for linoleic and arachidonic acid metabolites. PPAR-delta promotes colonic tumorigenesis. NSAIDs suppress PPAR-delta activity in colon cancer cells. The mechanistic relationship between 15-LOX-1 and PPAR-delta was previously unknown. Our current study shows that (i) 13-S-HODE binds to PPAR-delta, decreases PPAR-delta activation, and down-regulates PPAR-delta expression in colorectal cancer cells; (ii) the induction of 15-LOX-1 expression is a critical step in NSAID down-regulation of PPAR-delta and the resultant induction of apoptosis; and (iii) PPAR-delta is an important signaling receptor for 13-S-HODE-induced apoptosis. The in vivo relevance of these mechanistic findings was demonstrated in our tumorigenesis studies in nude mouse xenograft models. Our findings indicate that the down-regulation of PPAR-delta by 15-LOX-1 through 13-S-HODE is an apoptotic signaling pathway that is activated by NSAIDs. | lld:pubmed |
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| pubmed-article:12909723 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:12909723 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:12909723 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12909723 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:12909723 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:12909723 | pubmed:author | pubmed-author:WeiJiangJ | lld:pubmed |
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| pubmed-article:12909723 | pubmed:author | pubmed-author:MorrisJeffrey... | lld:pubmed |
| pubmed-article:12909723 | pubmed:author | pubmed-author:StimmelJulie... | lld:pubmed |
| pubmed-article:12909723 | pubmed:author | pubmed-author:ShureiqiImadI | lld:pubmed |
| pubmed-article:12909723 | pubmed:author | pubmed-author:LeesnitzerLis... | lld:pubmed |
| pubmed-article:12909723 | pubmed:author | pubmed-author:FanHui-ZhenHZ | lld:pubmed |
| pubmed-article:12909723 | pubmed:author | pubmed-author:ZuoXiangsheng... | lld:pubmed |
| pubmed-article:12909723 | pubmed:author | pubmed-author:WuYuanqingY | lld:pubmed |
| pubmed-article:12909723 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12909723 | pubmed:day | 19 | lld:pubmed |
| pubmed-article:12909723 | pubmed:volume | 100 | lld:pubmed |
| pubmed-article:12909723 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12909723 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12909723 | pubmed:pagination | 9968-73 | lld:pubmed |
| pubmed-article:12909723 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:12909723 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12909723 | pubmed:articleTitle | The 15-lipoxygenase-1 product 13-S-hydroxyoctadecadienoic acid down-regulates PPAR-delta to induce apoptosis in colorectal cancer cells. | lld:pubmed |
| pubmed-article:12909723 | pubmed:affiliation | Departments of Clinical Cancer Prevention, University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA. ishureiqi@mdanderson.org | lld:pubmed |
| pubmed-article:12909723 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12909723 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:12909723 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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