| pubmed-article:12900519 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12900519 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:12900519 | lifeskim:mentions | umls-concept:C0021745 | lld:lifeskim |
| pubmed-article:12900519 | lifeskim:mentions | umls-concept:C1519680 | lld:lifeskim |
| pubmed-article:12900519 | lifeskim:mentions | umls-concept:C1823153 | lld:lifeskim |
| pubmed-article:12900519 | lifeskim:mentions | umls-concept:C0449416 | lld:lifeskim |
| pubmed-article:12900519 | lifeskim:mentions | umls-concept:C1705241 | lld:lifeskim |
| pubmed-article:12900519 | lifeskim:mentions | umls-concept:C0439097 | lld:lifeskim |
| pubmed-article:12900519 | lifeskim:mentions | umls-concept:C2349976 | lld:lifeskim |
| pubmed-article:12900519 | lifeskim:mentions | umls-concept:C1552644 | lld:lifeskim |
| pubmed-article:12900519 | lifeskim:mentions | umls-concept:C1999230 | lld:lifeskim |
| pubmed-article:12900519 | lifeskim:mentions | umls-concept:C1547348 | lld:lifeskim |
| pubmed-article:12900519 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:12900519 | pubmed:dateCreated | 2003-8-5 | lld:pubmed |
| pubmed-article:12900519 | pubmed:abstractText | Interferon (IFN)-gamma is necessary for tumor immunity, however, its initial cellular source is unknown. Because gammadelta T cells primarily produce this cytokine upon activation, we hypothesized that they would provide an important early source of IFN-gamma in tumor immunosurveillance. To address this hypothesis, we first demonstrated that gammadelta T cell-deficient mice had a significantly higher incidence of tumor development after challenge with a chemical carcinogen methylcholanthrene (MCA) or inoculation with the melanoma cell line B16. In wild-type mice, gammadelta T cells were recruited to the site of tumor as early as day 3 after inoculation, followed by alphabeta T cells at day 5. We then used bone marrow chimeras and fetal liver reconstitutions to create mice with an intact gammadelta T cell repertoire but one that was specifically deficient in the capacity to produce IFN-gamma. Such mice had a higher incidence of tumor development, induced either with MCA or by inoculation of B16 melanoma cells, compared with mice with IFN-gamma-competent gammadelta T cells. Moreover, genetic deficiency of gammadelta T cells resulted in impaired IFN-gamma production by tumor antigen-triggered alphabeta T cell upon immunization with tumor lysate. These results demonstrate that gammadelta T cells can play a necessary role in tumor immunity through provision of an early source of IFN-gamma that in turn may regulate the function of tumor-triggered alphabeta T cells. | lld:pubmed |
| pubmed-article:12900519 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12900519 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12900519 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12900519 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12900519 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12900519 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12900519 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12900519 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12900519 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12900519 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12900519 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12900519 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12900519 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12900519 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12900519 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12900519 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12900519 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12900519 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12900519 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12900519 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12900519 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12900519 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12900519 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12900519 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12900519 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12900519 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12900519 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12900519 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12900519 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12900519 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12900519 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12900519 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12900519 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12900519 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12900519 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12900519 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12900519 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12900519 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12900519 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12900519 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12900519 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12900519 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12900519 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12900519 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12900519 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12900519 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12900519 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12900519 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12900519 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12900519 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:12900519 | pubmed:issn | 0022-1007 | lld:pubmed |
| pubmed-article:12900519 | pubmed:author | pubmed-author:AugenlichtLeo... | lld:pubmed |
| pubmed-article:12900519 | pubmed:author | pubmed-author:YinZhinanZ | lld:pubmed |
| pubmed-article:12900519 | pubmed:author | pubmed-author:CraftJoeJ | lld:pubmed |
| pubmed-article:12900519 | pubmed:author | pubmed-author:GirardiMichae... | lld:pubmed |
| pubmed-article:12900519 | pubmed:author | pubmed-author:YangWancaiW | lld:pubmed |
| pubmed-article:12900519 | pubmed:author | pubmed-author:GaoYunfeiY | lld:pubmed |
| pubmed-article:12900519 | pubmed:author | pubmed-author:PanMengM | lld:pubmed |
| pubmed-article:12900519 | pubmed:author | pubmed-author:ScullyEileenE | lld:pubmed |
| pubmed-article:12900519 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12900519 | pubmed:day | 4 | lld:pubmed |
| pubmed-article:12900519 | pubmed:volume | 198 | lld:pubmed |
| pubmed-article:12900519 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12900519 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12900519 | pubmed:pagination | 433-42 | lld:pubmed |
| pubmed-article:12900519 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:12900519 | pubmed:meshHeading | pubmed-meshheading:12900519... | lld:pubmed |
| pubmed-article:12900519 | pubmed:meshHeading | pubmed-meshheading:12900519... | lld:pubmed |
| pubmed-article:12900519 | pubmed:meshHeading | pubmed-meshheading:12900519... | lld:pubmed |
| pubmed-article:12900519 | pubmed:meshHeading | pubmed-meshheading:12900519... | lld:pubmed |
| pubmed-article:12900519 | pubmed:meshHeading | pubmed-meshheading:12900519... | lld:pubmed |
| pubmed-article:12900519 | pubmed:meshHeading | pubmed-meshheading:12900519... | lld:pubmed |
| pubmed-article:12900519 | pubmed:meshHeading | pubmed-meshheading:12900519... | lld:pubmed |
| pubmed-article:12900519 | pubmed:meshHeading | pubmed-meshheading:12900519... | lld:pubmed |
| pubmed-article:12900519 | pubmed:meshHeading | pubmed-meshheading:12900519... | lld:pubmed |
| pubmed-article:12900519 | pubmed:meshHeading | pubmed-meshheading:12900519... | lld:pubmed |
| pubmed-article:12900519 | pubmed:meshHeading | pubmed-meshheading:12900519... | lld:pubmed |
| pubmed-article:12900519 | pubmed:meshHeading | pubmed-meshheading:12900519... | lld:pubmed |
| pubmed-article:12900519 | pubmed:meshHeading | pubmed-meshheading:12900519... | lld:pubmed |
| pubmed-article:12900519 | pubmed:meshHeading | pubmed-meshheading:12900519... | lld:pubmed |
| pubmed-article:12900519 | pubmed:meshHeading | pubmed-meshheading:12900519... | lld:pubmed |
| pubmed-article:12900519 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12900519 | pubmed:articleTitle | Gamma delta T cells provide an early source of interferon gamma in tumor immunity. | lld:pubmed |
| pubmed-article:12900519 | pubmed:affiliation | Section of Rheumatology, Yale School of Medicine, 300 Cedar Street, CAB Building Room S517, New Haven, CT 06520, USA. | lld:pubmed |
| pubmed-article:12900519 | pubmed:publicationType | Journal Article | lld:pubmed |
