Linked Life Data

12899540

Source:http://linkedlifedata.com/resource/pubmed/id/12899540

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pubmed-article:12899540pubmed:abstractTextPossible effects of 1,25-dihydoxyvitamin D3 (vitamin D) on ionizing radiation-induced cell damage have been unknown until now. The task of the present study was to analyze, in a human keratinocyte cell line (HaCaT), the effects of a preincubation with vitamin D on the X-ray-induced mRNA expression of different genes related to apoptosis (gene array). The first results show that ionizing radiation leads to a down-regulation of various apoptosis-relevant genes in HaCaT cells pretreated with vitamin D. Therefore it can be speculated that vitamin D could prove to be a promising radioprotective substance.lld:pubmed
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pubmed-article:12899540pubmed:pagination427-32lld:pubmed
pubmed-article:12899540pubmed:dateRevised2008-2-13lld:pubmed
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pubmed-article:12899540pubmed:articleTitleModulation of X-ray-induced apoptosis in human keratinocytes (HaCaT) by 1,25-dihydroxyvitamin D3.lld:pubmed
pubmed-article:12899540pubmed:affiliationInstitut für Radiobiologie der Bundeswehr, 80937 Munich, Germany. Viktor.Meineke@t-online.delld:pubmed
pubmed-article:12899540pubmed:publicationTypeJournal Articlelld:pubmed