| pubmed-article:12897139 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12897139 | lifeskim:mentions | umls-concept:C0225336 | lld:lifeskim |
| pubmed-article:12897139 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:12897139 | lifeskim:mentions | umls-concept:C0037083 | lld:lifeskim |
| pubmed-article:12897139 | lifeskim:mentions | umls-concept:C0053932 | lld:lifeskim |
| pubmed-article:12897139 | lifeskim:mentions | umls-concept:C1826624 | lld:lifeskim |
| pubmed-article:12897139 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:12897139 | lifeskim:mentions | umls-concept:C1159888 | lld:lifeskim |
| pubmed-article:12897139 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:12897139 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:12897139 | pubmed:issue | 16 | lld:pubmed |
| pubmed-article:12897139 | pubmed:dateCreated | 2003-8-4 | lld:pubmed |
| pubmed-article:12897139 | pubmed:abstractText | The development of endothelial cell precursors is essential for vasculogenesis. We screened for differentially expressed transcripts in endothelial cell precursors in developing mouse embryoid bodies. We cloned a complete cDNA encoding a protein that contains an amino-terminal signal peptide, five cysteine-rich domains, a von Willebrand D domain, and a trypsin inhibitor domain. We termed this protein BMPER (bone morphogenetic protein [BMP]-binding endothelial cell precursor-derived regulator). BMPER is specifically expressed in flk-1-positive cells and parallels the time course of flk-1 induction in these cells. In situ hybridization in mouse embryos demonstrates dorsal midline staining and staining of the aorto-gonadal-mesonephric region, which is known to host vascular precursor cells. BMPER is a secreted protein that directly interacts with BMP2, BMP4, and BMP6 and antagonizes BMP4-dependent Smad5 activation. In Xenopus embryos, ventral injection of BMPER mRNA results in axis duplication and downregulation of the expression of Xvent-1 (downstream target of Smad signaling). In an embryoid body differentiation assay, BMP4-dependent differentiation of endothelial cells in embryoid bodies is also antagonized by BMPER. Taken together, our data indicate that BMPER is a novel BMP-binding protein that is expressed by endothelial cell precursors, has BMP-antagonizing activity, and may play a role in endothelial cell differentiation by modulating local BMP activity. | lld:pubmed |
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| pubmed-article:12897139 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12897139 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12897139 | pubmed:citationSubset | IM | lld:pubmed |
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