Linked Life Data

12895451

Source:http://linkedlifedata.com/resource/pubmed/id/12895451

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pubmed-article:12895451pubmed:abstractTextThe Wobbler mouse is recognized as an animal model for motoneuron disease that exhibits motoneuron pathology. We have recently demonstrated the occurrence of mitochondrial dysfunction in the Wobbler mouse brain. The aim of the present study was to evaluate whether mitochondrial dysfunction occurred at an early age at the time where disease symptoms appear, and whether it was more pronounced in the motor cortex or in the spinal cord. We report here a significant decrease in mitochondrial state 3 and 4 respiration rates at an early age in the Wobbler spinal cord. In addition, there was a pronounced decrease in oxidative phosphorylation in mitochondria isolated from both spinal cord and motor cortex in both age groups. This mitochondrial dysfunction was accompanied by impairment of complex I activity in mitochondria isolated from spinal cord at an early age. Decreases in complex III and IV activities were observed only in mitochondria isolated from the motor cortex at an early age, but impairment of complex III activity prevailed until later in the disease. We conclude that mitochondrial dysfunction ensues at an early stage of the disease and is more pronounced in the spinal cord, which correlates with previous studies that reported degeneration of spinal cord motorneurons.lld:pubmed
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pubmed-article:12895451pubmed:pagination412-20lld:pubmed
pubmed-article:12895451pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:12895451pubmed:year2003lld:pubmed
pubmed-article:12895451pubmed:articleTitleEarly mitochondrial dysfunction occurs in motor cortex and spinal cord at the onset of disease in the Wobbler mouse.lld:pubmed
pubmed-article:12895451pubmed:affiliationDepartment of Neurology, University of Miami School of Medicine, Miami, FL 33101, USA.lld:pubmed
pubmed-article:12895451pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:12895451pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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