| pubmed-article:12888908 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12888908 | lifeskim:mentions | umls-concept:C0007600 | lld:lifeskim |
| pubmed-article:12888908 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:12888908 | lifeskim:mentions | umls-concept:C0699791 | lld:lifeskim |
| pubmed-article:12888908 | lifeskim:mentions | umls-concept:C0162638 | lld:lifeskim |
| pubmed-article:12888908 | lifeskim:mentions | umls-concept:C1518174 | lld:lifeskim |
| pubmed-article:12888908 | lifeskim:mentions | umls-concept:C0037083 | lld:lifeskim |
| pubmed-article:12888908 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:12888908 | pubmed:dateCreated | 2003-7-30 | lld:pubmed |
| pubmed-article:12888908 | pubmed:abstractText | The Fas-Fas ligand system is one of the factors involved in cell death signaling. Aberrations in the signaling pathways leading to Fas-mediated apoptosis in tumor cells have been reported in a variety of human malignant tumors. However, the Fas-mediated apoptotic pathway has not been sufficiently elucidated in human gastric carcinomas. We examined the apoptotic pathway induced by anti-Fas antibody using seven human gastric carcinoma cell lines. Apoptosis was induced in a delayed fashion and the apoptotic indices (AI) after 48 h were approximately 30-40% in MKN-45 and KATO-III cells, which both showed cleavage of the Bid protein and release of Cytochrome c from the mitochondria. Our data also demonstrated no significant relationship between the expressions of various apoptosis-related proteins and the sensitivity or resistance to anti-Fas antibody-induced apoptosis, as far as we examined. Furthermore, the apoptosis signal was inhibited by treatment with Caspase-9 and -3 inhibitors in MKN-45 and KATO-III. These findings suggest that anti-Fas antibody induced apoptosis through the type II signaling pathway in the human gastric carcinoma cell lines, MKN-45 and KATO-III. | lld:pubmed |
| pubmed-article:12888908 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12888908 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12888908 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12888908 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12888908 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12888908 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12888908 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12888908 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12888908 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12888908 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12888908 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12888908 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12888908 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:12888908 | pubmed:issn | 1019-6439 | lld:pubmed |
| pubmed-article:12888908 | pubmed:author | pubmed-author:ItoHisaoH | lld:pubmed |
| pubmed-article:12888908 | pubmed:author | pubmed-author:KaseSatoruS | lld:pubmed |
| pubmed-article:12888908 | pubmed:author | pubmed-author:OsakiMitsuhik... | lld:pubmed |
| pubmed-article:12888908 | pubmed:author | pubmed-author:AdachiKeikoK | lld:pubmed |
| pubmed-article:12888908 | pubmed:author | pubmed-author:TakedaAmiA | lld:pubmed |
| pubmed-article:12888908 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12888908 | pubmed:volume | 23 | lld:pubmed |
| pubmed-article:12888908 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12888908 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12888908 | pubmed:pagination | 713-9 | lld:pubmed |
| pubmed-article:12888908 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:12888908 | pubmed:meshHeading | pubmed-meshheading:12888908... | lld:pubmed |
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| pubmed-article:12888908 | pubmed:meshHeading | pubmed-meshheading:12888908... | lld:pubmed |
| pubmed-article:12888908 | pubmed:meshHeading | pubmed-meshheading:12888908... | lld:pubmed |
| pubmed-article:12888908 | pubmed:meshHeading | pubmed-meshheading:12888908... | lld:pubmed |
| pubmed-article:12888908 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12888908 | pubmed:articleTitle | Anti-Fas antibody-induced apoptosis and its signal transduction in human gastric carcinoma cell lines. | lld:pubmed |
| pubmed-article:12888908 | pubmed:affiliation | Division of Organ Pathology, Department of Microbiology and Pathology, Faculty of Medicine, Tottori University, 86 Nishi-cho, Yonago, Tottori 683-8503, Japan. | lld:pubmed |
| pubmed-article:12888908 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12888908 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
