| pubmed-article:12888492 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12888492 | lifeskim:mentions | umls-concept:C0178453 | lld:lifeskim |
| pubmed-article:12888492 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:12888492 | lifeskim:mentions | umls-concept:C1159782 | lld:lifeskim |
| pubmed-article:12888492 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:12888492 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:12888492 | pubmed:issue | 15 | lld:pubmed |
| pubmed-article:12888492 | pubmed:dateCreated | 2003-7-30 | lld:pubmed |
| pubmed-article:12888492 | pubmed:abstractText | When iron repletes, Schizosaccharomyces pombe cells repress transcription of genes encoding components involved in the reductive iron transport system. Fep1 mediates this transcriptional control by interacting specifically with GATA-type cis-acting elements. To further investigate the role that Fep1 plays in iron homeostasis, we searched for additional Fep1-regulated genes. We found that str1+ is subject to negative transcriptional regulation, which is exerted through binding of Fep1 to a single GATA element in the str1+ promoter. Introduction of str1+ into a Saccharomyces cerevisiae fet3Delta arn1-4Delta strain led to assimilation of iron from ferrichrome, revealing that Str1 functions as a siderophore-iron transporter in S.pombe. We also identified two additional target genes of Fep1, named str2+ and str3+. We demonstrate that the str1+, str2+ and str3+ genes share a common promoter element, 5'-(A/T)GATAA-3'. We found that the N-terminal 241 residue segment of Fep1 expressed in Escherichia coli specifically interacts with the 5'-(A/T)GATAA-3' element present in each of these promoters. Consistent with this, constitutive high level str1+, str2+ and str3+ gene expression was observed in a fep1Delta mutant strain. Taken together, these results demonstrate that Fep1 occupies a central role in coordinating transcriptional regulation of genes encoding components of the reductive and non-reductive iron transport systems in fission yeast. | lld:pubmed |
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| pubmed-article:12888492 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12888492 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12888492 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12888492 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:12888492 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12888492 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:12888492 | pubmed:issn | 1362-4962 | lld:pubmed |
| pubmed-article:12888492 | pubmed:author | pubmed-author:PelletierBeno... | lld:pubmed |
| pubmed-article:12888492 | pubmed:author | pubmed-author:BeaudoinJudeJ | lld:pubmed |
| pubmed-article:12888492 | pubmed:author | pubmed-author:LabbéSimonS | lld:pubmed |
| pubmed-article:12888492 | pubmed:author | pubmed-author:PhilpottCarol... | lld:pubmed |
| pubmed-article:12888492 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:12888492 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:12888492 | pubmed:volume | 31 | lld:pubmed |
| pubmed-article:12888492 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12888492 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12888492 | pubmed:pagination | 4332-44 | lld:pubmed |
| pubmed-article:12888492 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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