| pubmed-article:12884301 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12884301 | lifeskim:mentions | umls-concept:C0021368 | lld:lifeskim |
| pubmed-article:12884301 | lifeskim:mentions | umls-concept:C0038250 | lld:lifeskim |
| pubmed-article:12884301 | lifeskim:mentions | umls-concept:C0024880 | lld:lifeskim |
| pubmed-article:12884301 | lifeskim:mentions | umls-concept:C1515655 | lld:lifeskim |
| pubmed-article:12884301 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:12884301 | pubmed:dateCreated | 2003-7-28 | lld:pubmed |
| pubmed-article:12884301 | pubmed:abstractText | We report that gp49B1, a mast cell membrane receptor with two immunoreceptor tyrosine-based inhibitory motifs (ITIM), constitutively inhibits mast cell activation-secretion induced by stem cell factor (SCF), a tissue-derived cytokine that also regulates mast cell development. The intradermal injection of SCF into the ears of gp49B1 null (gp49B(-/-)) mice elicited approximately 4- and 2.5-fold more degranulating mast cells and tissue swelling caused by edema, respectively, than in gp49B(+/+) mice. SCF did not induce tissue swelling in mast cell-deficient mice, and the responsiveness of gp49B(-/-) mice to mast cell-associated amine and lipid mediators was unaltered. When gp49B(+/+) and gp49B(-/-) mice were pretreated with antagonists of the amines, SCF-induced tissue swelling was reduced by >90% and 60%, respectively, and it was reduced by >90% in both genotypes when a cysteinyl leukotriene receptor antagonist was also provided. Hence, the dominant contribution of secretory granule amines to SCF-induced tissue swelling is the result of gp49B1-mediated inhibition of the production of cysteinyl leukotrienes by mast cells. Our findings also provide the first example of an ITIM-bearing receptor that constitutively suppresses inflammation generated in vivo independently of the adaptive immune response by a receptor that signals through intrinsic tyrosine kinase activity rather than immunoreceptor tyrosine-based activation motifs. | lld:pubmed |
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| pubmed-article:12884301 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12884301 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12884301 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:12884301 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12884301 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:12884301 | pubmed:issn | 0014-2980 | lld:pubmed |
| pubmed-article:12884301 | pubmed:author | pubmed-author:JooFF | lld:pubmed |
| pubmed-article:12884301 | pubmed:author | pubmed-author:KanaokaYoshih... | lld:pubmed |
| pubmed-article:12884301 | pubmed:author | pubmed-author:FriendDaniel... | lld:pubmed |
| pubmed-article:12884301 | pubmed:author | pubmed-author:AustenK... | lld:pubmed |
| pubmed-article:12884301 | pubmed:author | pubmed-author:KatzHoward... | lld:pubmed |
| pubmed-article:12884301 | pubmed:author | pubmed-author:DaheshiaMasso... | lld:pubmed |
| pubmed-article:12884301 | pubmed:author | pubmed-author:FeldwegAnna... | lld:pubmed |
| pubmed-article:12884301 | pubmed:author | pubmed-author:ZhouJoseph... | lld:pubmed |
| pubmed-article:12884301 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12884301 | pubmed:volume | 33 | lld:pubmed |
| pubmed-article:12884301 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12884301 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12884301 | pubmed:pagination | 2262-8 | lld:pubmed |
| pubmed-article:12884301 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:12884301 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12884301 | pubmed:articleTitle | gp49B1 suppresses stem cell factor-induced mast cell activation-secretion and attendant inflammation in vivo. | lld:pubmed |
| pubmed-article:12884301 | pubmed:affiliation | Department of Medicine, Harvard Medical School, Boston, USA. | lld:pubmed |
| pubmed-article:12884301 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12884301 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:12884301 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:14728 | entrezgene:pubmed | pubmed-article:12884301 | lld:entrezgene |
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