Linked Life Data

12884300

Source:http://linkedlifedata.com/resource/pubmed/id/12884300

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pubmed-article:12884300pubmed:abstractTextME3738 is a new compound that attenuates liver disease in several models of acute and chronic liver inflammation. We used the concanavalin A (Con A) model to elucidate the molecular mechanisms of ME3738 to block liver cell damage. Pretreatment of BALB/c mice with ME3738 prior to Con A injection resulted in a significant reduction in liver injury. The protective effect of ME3738 prior to Con A injection was associated with a reduction in IL-6 serum levels and NF-kappaB DNA binding in liver nuclear extracts. However, STAT3 DNA binding was induced via ME3738 prior to Con A injection. Further analysis showed that ME3738 induces IL-6 serum levels and activates STAT3 DNA binding and target gene transcription. The relevance of this finding was assessed in IL-6(-/-) mice. In these animals, ME3738 induced no increase in IL-6 serum expression, and activation of IL-6-dependent pathways was not found. In addition, ME3738 did not protect IL-6(-/-) animals from Con A-induced liver failure, while IL-6 injection was still effective. Therefore, we demonstrate that ME3738 triggers IL-6 expression, which activates pathways that are relevant to protect from Con A-induced liver failure.lld:pubmed
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pubmed-article:12884300pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:12884300pubmed:articleTitleME3738 protects from concanavalin A-induced liver failure via an IL-6-dependent mechanism.lld:pubmed
pubmed-article:12884300pubmed:affiliationDepartment of Gastroenterology, Hepatology and Endocrinology, Medizinische Hochschule Hannover, Hannover, Germany.lld:pubmed
pubmed-article:12884300pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:12884300pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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