pubmed-article:12883552 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:12883552 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
pubmed-article:12883552 | lifeskim:mentions | umls-concept:C0113519 | lld:lifeskim |
pubmed-article:12883552 | lifeskim:mentions | umls-concept:C0678226 | lld:lifeskim |
pubmed-article:12883552 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
pubmed-article:12883552 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
pubmed-article:12883552 | lifeskim:mentions | umls-concept:C0011155 | lld:lifeskim |
pubmed-article:12883552 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
pubmed-article:12883552 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
pubmed-article:12883552 | lifeskim:mentions | umls-concept:C2349975 | lld:lifeskim |
pubmed-article:12883552 | lifeskim:mentions | umls-concept:C1719914 | lld:lifeskim |
pubmed-article:12883552 | lifeskim:mentions | umls-concept:C2828406 | lld:lifeskim |
pubmed-article:12883552 | pubmed:issue | 9 | lld:pubmed |
pubmed-article:12883552 | pubmed:dateCreated | 2003-8-27 | lld:pubmed |
pubmed-article:12883552 | pubmed:abstractText | Much is known about how T cell receptor (TCR) engagement leads to T cell activation; however, the mechanisms terminating TCR signaling remain less clear. Diacylglycerol, generated after TCR ligation, is essential in T cells. Its function must be controlled tightly to maintain normal T cell homeostasis. Previous studies have shown that diacylglycerol kinase zeta (DGKzeta), which converts diacylglycerol to phosphatidic acid, can inhibit TCR signaling. Here we show that DGKzeta-deficient T cells are hyperresponsive to TCR stimulation both ex vivo and in vivo. Furthermore, DGKzeta-deficient mice mounted a more robust immune response to lymphocytic choriomeningitis virus infection than did wild-type mice. These results demonstrate the importance of DGKzeta as a physiological negative regulator of TCR signaling and T cell activation. | lld:pubmed |
pubmed-article:12883552 | pubmed:language | eng | lld:pubmed |
pubmed-article:12883552 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:12883552 | pubmed:citationSubset | IM | lld:pubmed |
pubmed-article:12883552 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:12883552 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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pubmed-article:12883552 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:12883552 | pubmed:month | Sep | lld:pubmed |
pubmed-article:12883552 | pubmed:issn | 1529-2908 | lld:pubmed |
pubmed-article:12883552 | pubmed:author | pubmed-author:ShinJ HJH | lld:pubmed |
pubmed-article:12883552 | pubmed:author | pubmed-author:KoretzkyGary... | lld:pubmed |
pubmed-article:12883552 | pubmed:author | pubmed-author:ZhongXiao-Pin... | lld:pubmed |
pubmed-article:12883552 | pubmed:author | pubmed-author:HaineyEhmonie... | lld:pubmed |
pubmed-article:12883552 | pubmed:author | pubmed-author:OlenchockBenj... | lld:pubmed |
pubmed-article:12883552 | pubmed:author | pubmed-author:JordanMartha... | lld:pubmed |
pubmed-article:12883552 | pubmed:author | pubmed-author:NicholsKim... | lld:pubmed |
pubmed-article:12883552 | pubmed:author | pubmed-author:MaltzmanJonat... | lld:pubmed |
pubmed-article:12883552 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:12883552 | pubmed:volume | 4 | lld:pubmed |
pubmed-article:12883552 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:12883552 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:12883552 | pubmed:pagination | 882-90 | lld:pubmed |
pubmed-article:12883552 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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pubmed-article:12883552 | pubmed:year | 2003 | lld:pubmed |
pubmed-article:12883552 | pubmed:articleTitle | Enhanced T cell responses due to diacylglycerol kinase zeta deficiency. | lld:pubmed |
pubmed-article:12883552 | pubmed:affiliation | The Signal Transduction Program, The Abramson Family Cancer Research Institute, Philadelphia, Pennsylvania 19104, USA. | lld:pubmed |
pubmed-article:12883552 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:12883552 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
pubmed-article:12883552 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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