| pubmed-article:12882930 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12882930 | lifeskim:mentions | umls-concept:C0011881 | lld:lifeskim |
| pubmed-article:12882930 | lifeskim:mentions | umls-concept:C0039840 | lld:lifeskim |
| pubmed-article:12882930 | lifeskim:mentions | umls-concept:C1708528 | lld:lifeskim |
| pubmed-article:12882930 | lifeskim:mentions | umls-concept:C0053116 | lld:lifeskim |
| pubmed-article:12882930 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:12882930 | pubmed:dateCreated | 2003-7-28 | lld:pubmed |
| pubmed-article:12882930 | pubmed:abstractText | Accumulation of triosephosphates arising from high cytosolic glucose concentrations in hyperglycemia is the trigger for biochemical dysfunction leading to the development of diabetic nephropathy-a common complication of diabetes associated with a high risk of cardiovascular disease and mortality. Here we report that stimulation of the reductive pentosephosphate pathway by high-dose therapy with thiamine and the thiamine monophosphate derivative benfotiamine countered the accumulation of triosephosphates in experimental diabetes and inhibited the development of incipient nephropathy. High-dose thiamine and benfotiamine therapy increased transketolase expression in renal glomeruli, increased the conversion of triosephosphates to ribose-5-phosphate, and strongly inhibited the development of microalbuminuria. This was associated with decreased activation of protein kinase C and decreased protein glycation and oxidative stress-three major pathways of biochemical dysfunction in hyperglycemia. Benfotiamine also inhibited diabetes-induced hyperfiltration. This was achieved without change in elevated plasma glucose concentration and glycated hemoglobin in the diabetic state. High-dose thiamine and benfotiamine therapy is a potential novel strategy for the prevention of clinical diabetic nephropathy. | lld:pubmed |
| pubmed-article:12882930 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12882930 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12882930 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:12882930 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12882930 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:12882930 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12882930 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12882930 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:12882930 | pubmed:issn | 0012-1797 | lld:pubmed |
| pubmed-article:12882930 | pubmed:author | pubmed-author:ThornalleyPau... | lld:pubmed |
| pubmed-article:12882930 | pubmed:author | pubmed-author:AhmedNailaN | lld:pubmed |
| pubmed-article:12882930 | pubmed:author | pubmed-author:BattahSinanS | lld:pubmed |
| pubmed-article:12882930 | pubmed:author | pubmed-author:Babaei-Jadidi... | lld:pubmed |
| pubmed-article:12882930 | pubmed:author | pubmed-author:KarachaliasNi... | lld:pubmed |
| pubmed-article:12882930 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12882930 | pubmed:volume | 52 | lld:pubmed |
| pubmed-article:12882930 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12882930 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12882930 | pubmed:pagination | 2110-20 | lld:pubmed |
| pubmed-article:12882930 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:12882930 | pubmed:meshHeading | pubmed-meshheading:12882930... | lld:pubmed |
| pubmed-article:12882930 | pubmed:meshHeading | pubmed-meshheading:12882930... | lld:pubmed |
| pubmed-article:12882930 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12882930 | pubmed:articleTitle | Prevention of incipient diabetic nephropathy by high-dose thiamine and benfotiamine. | lld:pubmed |
| pubmed-article:12882930 | pubmed:affiliation | Department of Biological Sciences, University of Essex, Central Campus, Wivenhoe Park, Colchester, Essex, UK. | lld:pubmed |
| pubmed-article:12882930 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12882930 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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