| pubmed-article:12878759 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12878759 | lifeskim:mentions | umls-concept:C0036945 | lld:lifeskim |
| pubmed-article:12878759 | lifeskim:mentions | umls-concept:C0025663 | lld:lifeskim |
| pubmed-article:12878759 | lifeskim:mentions | umls-concept:C0228174 | lld:lifeskim |
| pubmed-article:12878759 | lifeskim:mentions | umls-concept:C0025519 | lld:lifeskim |
| pubmed-article:12878759 | lifeskim:mentions | umls-concept:C1550235 | lld:lifeskim |
| pubmed-article:12878759 | lifeskim:mentions | umls-concept:C0521457 | lld:lifeskim |
| pubmed-article:12878759 | lifeskim:mentions | umls-concept:C0242184 | lld:lifeskim |
| pubmed-article:12878759 | lifeskim:mentions | umls-concept:C0242485 | lld:lifeskim |
| pubmed-article:12878759 | lifeskim:mentions | umls-concept:C0018841 | lld:lifeskim |
| pubmed-article:12878759 | lifeskim:mentions | umls-concept:C1947917 | lld:lifeskim |
| pubmed-article:12878759 | lifeskim:mentions | umls-concept:C0549178 | lld:lifeskim |
| pubmed-article:12878759 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:12878759 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:12878759 | lifeskim:mentions | umls-concept:C1705938 | lld:lifeskim |
| pubmed-article:12878759 | lifeskim:mentions | umls-concept:C1527178 | lld:lifeskim |
| pubmed-article:12878759 | pubmed:issue | Pt 1 | lld:pubmed |
| pubmed-article:12878759 | pubmed:dateCreated | 2003-10-2 | lld:pubmed |
| pubmed-article:12878759 | pubmed:abstractText | This study was undertaken to validate a new method of measuring cerebral metabolic rate in the fetal sheep based on heat production in a local region of the brain. Heat production was compared to oxygen use in 20 near-term fetuses during basal conditions, moderate hypoxia and cord occlusion. Thermocouples were placed to measure core and brain temperature and a composite probe placed in the parietal cortex to measure changes in cortical blood flow (CBF) using laser Doppler flowmetry and tissue PO2 using fluorescent decay. Catheters were inserted in a brachiocephalic artery and sagittal sinus for blood sampling. With moderate hypoxia, induced by administering 10-12 % oxygen to the ewes, fetal arterial PO2 declined from 23 +/- 1 to 11 +/- 1 Torr and brain tissue PO2 fell from 7.6+/- 0.7 to a nadir of 0.8 +/- 0.4 Torr, while CBF increased to 139 +/- 5 % of baseline. Cortical heat production, calculated as the product of CBF, the temperature gain from artery to brain tissue, and the specific heat of blood, decreased by 45 +/- 11 % in parallel to similar declines in oxygen uptake. With severe asphyxia induced by complete cord occlusion for 10 min, fetal arterial PO2 declined from 23 +/- 1 to 9 +/- 2 Torr and brain tissue PO2 fell from 7.0 +/- 0.7 to essentially 0 Torr while CBF decreased 40 +/- 5 %. Cortical heat production decreased by 78 +/- 6 % while oxygen use declined by 90 +/- 3 %. Glucose uptake increased significantly relative to oxygen use and lactate concentration increased in sagittal sinus blood. We conclude that local measurements of heat production in the brain provide a useful index of overall metabolic rate, closely reflecting oxygen use in moderate hypoxia and indicating a significant contribution from anaerobic metabolism during severe asphyxia. | lld:pubmed |
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| pubmed-article:12878759 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12878759 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12878759 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:12878759 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12878759 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:12878759 | pubmed:issn | 0022-3751 | lld:pubmed |
| pubmed-article:12878759 | pubmed:author | pubmed-author:BloodArlin... | lld:pubmed |
| pubmed-article:12878759 | pubmed:author | pubmed-author:PowerGordon... | lld:pubmed |
| pubmed-article:12878759 | pubmed:author | pubmed-author:HunterChristi... | lld:pubmed |
| pubmed-article:12878759 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12878759 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:12878759 | pubmed:volume | 552 | lld:pubmed |
| pubmed-article:12878759 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12878759 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12878759 | pubmed:pagination | 241-51 | lld:pubmed |
| pubmed-article:12878759 | pubmed:dateRevised | 2010-9-14 | lld:pubmed |
| pubmed-article:12878759 | pubmed:meshHeading | pubmed-meshheading:12878759... | lld:pubmed |
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| pubmed-article:12878759 | pubmed:meshHeading | pubmed-meshheading:12878759... | lld:pubmed |
| pubmed-article:12878759 | pubmed:meshHeading | pubmed-meshheading:12878759... | lld:pubmed |
| pubmed-article:12878759 | pubmed:meshHeading | pubmed-meshheading:12878759... | lld:pubmed |
| pubmed-article:12878759 | pubmed:meshHeading | pubmed-meshheading:12878759... | lld:pubmed |
| pubmed-article:12878759 | pubmed:meshHeading | pubmed-meshheading:12878759... | lld:pubmed |
| pubmed-article:12878759 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12878759 | pubmed:articleTitle | Cerebral metabolism during cord occlusion and hypoxia in the fetal sheep: a novel method of continuous measurement based on heat production. | lld:pubmed |
| pubmed-article:12878759 | pubmed:affiliation | Center for Perinatal Biology, Loma Linda University School of Medicine, Loma Linda, CA 92350, USA. | lld:pubmed |
| pubmed-article:12878759 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12878759 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
