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pubmed-article:12877588pubmed:dateCreated2003-7-24lld:pubmed
pubmed-article:12877588pubmed:abstractTextThree novel Pt(II) complexes [PtL(1)'Cl] I (L(1)' = glycine-N'-8-quinolylamide), [PtL(2)'Cl] II (L(2)' = l-alanine-N'-8-quinolylamide), and [PtL(3)Cl] III [L(3) = N-(tert-butoxycarbonyl)-l-methionine-N'-8-quinolylamide] have been synthesized and characterized. The crystal structure of complexes II and III showed that the ligands are three-coordinated with only one Cl(-) as the leaving group. Complex II crystallized in the monoclinic system with space group P2(1), a = 9.502(2) A, b = 4.724(1) A, c = 14.800(3) A, while complex III crystallized in the orthorhombic system with space group P2(1)2(1)2(1), a = 5.441(1) A, b = 12.978(3) A, c = 29.438(6) A. These complexes have been tested against a wide range of tumor cell lines including BEL-7402, HCT-116, SPC-A4, MOLT-4, P388, HL-60, A-549, SGC-7901, MKN-28, and HO-8910. Complex III is highly cytotoxic against the HCT-116 (IC(50) = 0.38 microM), SPC-A4 (IC(50) = 0.43 microM), BEL-7402 (IC(50) = 0.43 microM), and MOLT-4 (IC(50) = 0.61 microM) cell lines. The cell line most sensitive to III is human liver carcinoma cell line BEL-7402, which has a response rate of 75.1% at 6.6 x 10(-7) M, nearly 6 times higher than that of cisplatin.lld:pubmed
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pubmed-article:12877588pubmed:authorpubmed-author:HeChengClld:pubmed
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pubmed-article:12877588pubmed:authorpubmed-author:LinJunJlld:pubmed
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pubmed-article:12877588pubmed:authorpubmed-author:YouXiaozengXlld:pubmed
pubmed-article:12877588pubmed:authorpubmed-author:WangXiaoyongXlld:pubmed
pubmed-article:12877588pubmed:authorpubmed-author:ZhangJunyongJlld:pubmed
pubmed-article:12877588pubmed:authorpubmed-author:TuChaoClld:pubmed
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pubmed-article:12877588pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:12877588pubmed:year2003lld:pubmed
pubmed-article:12877588pubmed:articleTitleMonofunctional platinum complexes showing potent cytotoxicity against human liver carcinoma cell line BEL-7402.lld:pubmed
pubmed-article:12877588pubmed:affiliationState Key Laboratory of Coordination Chemistry, Coordination Chemistry Institute, Nanjing University, Nanjing 210093, P. R. China.lld:pubmed
pubmed-article:12877588pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:12877588pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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