| pubmed-article:12874226 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12874226 | lifeskim:mentions | umls-concept:C0258432 | lld:lifeskim |
| pubmed-article:12874226 | lifeskim:mentions | umls-concept:C0296250 | lld:lifeskim |
| pubmed-article:12874226 | lifeskim:mentions | umls-concept:C1705639 | lld:lifeskim |
| pubmed-article:12874226 | lifeskim:mentions | umls-concept:C2752541 | lld:lifeskim |
| pubmed-article:12874226 | lifeskim:mentions | umls-concept:C1334333 | lld:lifeskim |
| pubmed-article:12874226 | lifeskim:mentions | umls-concept:C0599177 | lld:lifeskim |
| pubmed-article:12874226 | lifeskim:mentions | umls-concept:C1158950 | lld:lifeskim |
| pubmed-article:12874226 | lifeskim:mentions | umls-concept:C1707511 | lld:lifeskim |
| pubmed-article:12874226 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:12874226 | pubmed:dateCreated | 2003-7-22 | lld:pubmed |
| pubmed-article:12874226 | pubmed:abstractText | We have shown previously that Wiskott-Aldrich syndrome protein (WASP) activation at the site of T cell-APC interaction is a two-step process, with recruitment dependent on the proline-rich domain and activation dependent on binding of Cdc42-GTP to the GTPase binding domain. Here, we show that WASP recruitment occurs through binding to the C-terminal Src homology 3 domain of Nck. In contrast, WASP activation requires Vav-1. In Vav-1-deficient T cells, WASP recruitment proceeds normally, but localized activation of Cdc42 and WASP is disrupted. The recruitment and activation of WASP are coordinated by tyrosine-phosphorylated Src homology 2 domain-containing leukocyte protein of 76 kDa, which functions as a scaffold, bringing Nck and WASP into proximity with Vav-1 and Cdc42-GTP. Taken together, these findings reconstruct the signaling pathway leading from TCR ligation to localized WASP activation. | lld:pubmed |
| pubmed-article:12874226 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12874226 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12874226 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12874226 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:12874226 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:12874226 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12874226 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:12874226 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:12874226 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12874226 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12874226 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12874226 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12874226 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12874226 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12874226 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12874226 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:12874226 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:12874226 | pubmed:author | pubmed-author:WayMichaelM | lld:pubmed |
| pubmed-article:12874226 | pubmed:author | pubmed-author:AbrahamRobert... | lld:pubmed |
| pubmed-article:12874226 | pubmed:author | pubmed-author:BurkhardtJani... | lld:pubmed |
| pubmed-article:12874226 | pubmed:author | pubmed-author:ZengRongR | lld:pubmed |
| pubmed-article:12874226 | pubmed:author | pubmed-author:BilladeauDani... | lld:pubmed |
| pubmed-article:12874226 | pubmed:author | pubmed-author:CannonJudy... | lld:pubmed |
| pubmed-article:12874226 | pubmed:author | pubmed-author:Bubeck-Warden... | lld:pubmed |
| pubmed-article:12874226 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12874226 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:12874226 | pubmed:volume | 171 | lld:pubmed |
| pubmed-article:12874226 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12874226 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12874226 | pubmed:pagination | 1360-8 | lld:pubmed |
| pubmed-article:12874226 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:12874226 | pubmed:meshHeading | pubmed-meshheading:12874226... | lld:pubmed |
| pubmed-article:12874226 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12874226 | pubmed:articleTitle | SLP-76 coordinates Nck-dependent Wiskott-Aldrich syndrome protein recruitment with Vav-1/Cdc42-dependent Wiskott-Aldrich syndrome protein activation at the T cell-APC contact site. | lld:pubmed |
| pubmed-article:12874226 | pubmed:affiliation | Department of Pathology, University of Chicago, Chicago, IL 60637, USA. | lld:pubmed |
| pubmed-article:12874226 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12874226 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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