| pubmed-article:12874088 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12874088 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:12874088 | lifeskim:mentions | umls-concept:C0020538 | lld:lifeskim |
| pubmed-article:12874088 | lifeskim:mentions | umls-concept:C0003009 | lld:lifeskim |
| pubmed-article:12874088 | lifeskim:mentions | umls-concept:C0010592 | lld:lifeskim |
| pubmed-article:12874088 | lifeskim:mentions | umls-concept:C0162772 | lld:lifeskim |
| pubmed-article:12874088 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:12874088 | pubmed:dateCreated | 2003-10-3 | lld:pubmed |
| pubmed-article:12874088 | pubmed:abstractText | Treatment with cyclosporine A (CysA), a potent immunosuppressive agent, is associated with systemic and renal vasoconstriction, leading to hypertension. The present study was conducted to elucidate the contribution of angiotensin II (Ang II) to CysA-induced hypertension and reactive oxygen species (ROS) generation. CysA (30 mg/kg per day SC), given for 3 weeks in rats, increased systolic blood pressure (SBP) from 119+/-2 to 145+/-3 mm Hg (n=7). Plasma and kidney Ang II levels were significantly higher in CysA-treated rats (136+/-10 fmol/mL and 516+/-70 fmol/g) than in vehicle-treated (1 mL olive oil) rats (76+/-10 fmol/mL and 222+/-21 fmol/g, n=7). CysA treatment increased AT1 receptor protein expression in the aorta (by 251+/-35%), whereas it was reduced in the kidney (by -32+/-4%). Superoxide anion production in aortic segments and kidney thiobarbituric acid-reactive substance (TBARS) contents were higher in CysA-treated rats (26+/-2 counts/min per milligram and 37+/-3 nmol/g) than in vehicle-treated rats (17+/-1 counts/min per milligram and 24+/-3 nmol/g). Concurrent administration of an AT1 receptor antagonist, valsartan (30 mg/kg per day, in drinking water), to CysA-treated rats (n=7) significantly decreased SBP (113+/-4 mm Hg) and prevented increases in vascular superoxide (16+/-2 counts/min per milligram) and kidney TBARS contents (21+/-3 nmol/g). Similarly, treatment with a superoxide dismutase mimetic, 4-hydroxy-2,2,6,6,-tetramethylpiperidine-N-oxyl (Tempol; 3 mmol/L in drinking water, n=7), prevented CysA-induced increases in SBP (115+/-3 mm Hg), vascular superoxide (16+/-1 counts/min per milligram), and kidney TBARS contents (19+/-2 nmol/g). These data suggest that ROS generation induced by augmented Ang II levels contributes to the development of CysA-induced hypertension. | lld:pubmed |
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| pubmed-article:12874088 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:12874088 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:12874088 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12874088 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:12874088 | pubmed:issn | 1524-4563 | lld:pubmed |
| pubmed-article:12874088 | pubmed:author | pubmed-author:KoboriHiroyuk... | lld:pubmed |
| pubmed-article:12874088 | pubmed:author | pubmed-author:NishiyamaAkir... | lld:pubmed |
| pubmed-article:12874088 | pubmed:author | pubmed-author:KimuraShojiS | lld:pubmed |
| pubmed-article:12874088 | pubmed:author | pubmed-author:FukuiToshikiT | lld:pubmed |
| pubmed-article:12874088 | pubmed:author | pubmed-author:RahmanMatlubu... | lld:pubmed |
| pubmed-article:12874088 | pubmed:author | pubmed-author:AbeYouichiY | lld:pubmed |
| pubmed-article:12874088 | pubmed:author | pubmed-author:YaoLiL | lld:pubmed |
| pubmed-article:12874088 | pubmed:author | pubmed-author:KiyomotoHidey... | lld:pubmed |
| pubmed-article:12874088 | pubmed:author | pubmed-author:HitomiHirofum... | lld:pubmed |
| pubmed-article:12874088 | pubmed:author | pubmed-author:KohnoMasakazu... | lld:pubmed |
| pubmed-article:12874088 | pubmed:author | pubmed-author:ShokojiTakato... | lld:pubmed |
| pubmed-article:12874088 | pubmed:author | pubmed-author:ZhangGuo-Xing... | lld:pubmed |
| pubmed-article:12874088 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:12874088 | pubmed:volume | 42 | lld:pubmed |
| pubmed-article:12874088 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12874088 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12874088 | pubmed:pagination | 754-60 | lld:pubmed |
| pubmed-article:12874088 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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