pubmed-article:12874087 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:12874087 | lifeskim:mentions | umls-concept:C0020538 | lld:lifeskim |
pubmed-article:12874087 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
pubmed-article:12874087 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
pubmed-article:12874087 | lifeskim:mentions | umls-concept:C0014939 | lld:lifeskim |
pubmed-article:12874087 | lifeskim:mentions | umls-concept:C1098320 | lld:lifeskim |
pubmed-article:12874087 | lifeskim:mentions | umls-concept:C1412113 | lld:lifeskim |
pubmed-article:12874087 | lifeskim:mentions | umls-concept:C1527148 | lld:lifeskim |
pubmed-article:12874087 | lifeskim:mentions | umls-concept:C1555029 | lld:lifeskim |
pubmed-article:12874087 | lifeskim:mentions | umls-concept:C0231491 | lld:lifeskim |
pubmed-article:12874087 | pubmed:issue | 4 | lld:pubmed |
pubmed-article:12874087 | pubmed:dateCreated | 2003-10-3 | lld:pubmed |
pubmed-article:12874087 | pubmed:abstractText | The influence of estrogen on the regulation of cardiovascular function remains a controversial and complex area of investigation. We assessed the effects of estrogen depletion in the congenic mRen(2). Lewis rat, established from the back-cross of the original (mRen2)-27 transgenic onto the Lewis inbred strain. Ovariectomy of heterozygous mRen(2). Lewis at 4 to 5 weeks resulted in a progressive increase in blood pressure compared with the sham surgery congenics at weeks 6 to 11. At 11 weeks, the ovariectomized mRen(2). Lewis (OVX) systolic blood pressure averaged 195+/-3.7 mm Hg versus 141+/-4.0 mm Hg for sham. Plasma Angiotensin (Ang) II, serum ACE activity, plasma renin concentration, as well as urinary excretion of Ang II, 8-isoprostane F2alpha, and endothelin-1 were elevated; however, renal mRNA levels of eNOS were suppressed after ovariectomy. Estrogen replacement reduced blood pressure below both the sham and OVX by 11 weeks (125+/-2.9 mm Hg, n=7, P<0.01 versus OVX and sham). Moreover, the AT1 receptor antagonist olmesartan (CS866; week 12 to 16) essentially normalized blood pressure to 113+/-5.4 mm Hg (n=6, P<0.01 versus OVX and sham). The attenuation of the hypertension was still evident 7 weeks after complete withdrawal of treatment (124+/-4.1 mm Hg at week 23). In summary, the OVX mRen.2. Lewis exhibited a rapid and sustained increase in blood pressure. Estrogen or olmesartan lowered pressure by a similar extent. We conclude that the ovary exerts considerable influence on the regulation of the blood pressure in the mRen2. Lewis strain, possibly by limiting activation of the renin-angiotensin system. | lld:pubmed |
pubmed-article:12874087 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:12874087 | pubmed:language | eng | lld:pubmed |
pubmed-article:12874087 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:12874087 | pubmed:citationSubset | IM | lld:pubmed |
pubmed-article:12874087 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:12874087 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:12874087 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:12874087 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:12874087 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:12874087 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:12874087 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:12874087 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:12874087 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:12874087 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:12874087 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:12874087 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:12874087 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:12874087 | pubmed:month | Oct | lld:pubmed |
pubmed-article:12874087 | pubmed:issn | 1524-4563 | lld:pubmed |
pubmed-article:12874087 | pubmed:author | pubmed-author:FerrarioCarlo... | lld:pubmed |
pubmed-article:12874087 | pubmed:author | pubmed-author:BrosnihanK... | lld:pubmed |
pubmed-article:12874087 | pubmed:author | pubmed-author:GallagherPatr... | lld:pubmed |
pubmed-article:12874087 | pubmed:author | pubmed-author:AverillDavid... | lld:pubmed |
pubmed-article:12874087 | pubmed:author | pubmed-author:ChappellMark... | lld:pubmed |
pubmed-article:12874087 | pubmed:issnType | Electronic | lld:pubmed |
pubmed-article:12874087 | pubmed:volume | 42 | lld:pubmed |
pubmed-article:12874087 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:12874087 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:12874087 | pubmed:pagination | 781-6 | lld:pubmed |
pubmed-article:12874087 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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pubmed-article:12874087 | pubmed:meshHeading | pubmed-meshheading:12874087... | lld:pubmed |
pubmed-article:12874087 | pubmed:year | 2003 | lld:pubmed |
pubmed-article:12874087 | pubmed:articleTitle | Estrogen or the AT1 antagonist olmesartan reverses the development of profound hypertension in the congenic mRen2. Lewis rat. | lld:pubmed |
pubmed-article:12874087 | pubmed:affiliation | Hypertension and Vascular Disease Center, Wake Forest University Health Sciences, Medical Center Boulevard, Winston-Salem, NC 27157-1095, USA. mchappel@wfubmc.edu | lld:pubmed |
pubmed-article:12874087 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:12874087 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
pubmed-article:12874087 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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