| pubmed-article:12871940 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12871940 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:12871940 | lifeskim:mentions | umls-concept:C0031603 | lld:lifeskim |
| pubmed-article:12871940 | lifeskim:mentions | umls-concept:C0030013 | lld:lifeskim |
| pubmed-article:12871940 | lifeskim:mentions | umls-concept:C0439064 | lld:lifeskim |
| pubmed-article:12871940 | lifeskim:mentions | umls-concept:C1706062 | lld:lifeskim |
| pubmed-article:12871940 | lifeskim:mentions | umls-concept:C2587213 | lld:lifeskim |
| pubmed-article:12871940 | pubmed:issue | 40 | lld:pubmed |
| pubmed-article:12871940 | pubmed:dateCreated | 2003-9-29 | lld:pubmed |
| pubmed-article:12871940 | pubmed:abstractText | Phosphate (Pi) is a putative cytosolic signaling molecule in the regulation of oxidative phosphorylation. Here, by using a multiparameter monitoring system, we show that Pi controls oxidative phosphorylation in a balanced fashion, modulating both the generation of useful potential energy and the formation of ATP by F1F0-ATPase in heart and skeletal muscle mitochondria. In these studies the effect of Pi was determined on the mitochondria [NADH], NADH generating capacity, matrix pH, membrane potential, oxygen consumption, and cytochrome reduction level. Pi enhanced NADH generation and was obligatory for electron flow under uncoupled conditions. Pi oxidized cytochrome b (cyto-b) and reduced cytochrome c (cyto-c), potentially improving the coupling between the NADH free energy and the proton motive force. The apparent limitation in reducing equivalent flow between cyto-b and cyto-c in the absence of Pi was confirmed in the intact heart by using optical spectroscopic techniques under conditions with low cytosolic [Pi]. These results demonstrate that Pi signaling results in the balanced modulation of oxidative phosphorylation, by influencing both deltaGH+ generation and ATP production, which may contribute to the energy metabolism homeostasis observed in intact systems. | lld:pubmed |
| pubmed-article:12871940 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12871940 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12871940 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12871940 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:12871940 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12871940 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12871940 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:12871940 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:12871940 | pubmed:author | pubmed-author:BalabanRobert... | lld:pubmed |
| pubmed-article:12871940 | pubmed:author | pubmed-author:BoseSalilS | lld:pubmed |
| pubmed-article:12871940 | pubmed:author | pubmed-author:EvansFrank... | lld:pubmed |
| pubmed-article:12871940 | pubmed:author | pubmed-author:FrenchStephan... | lld:pubmed |
| pubmed-article:12871940 | pubmed:author | pubmed-author:JoubertFredri... | lld:pubmed |
| pubmed-article:12871940 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12871940 | pubmed:day | 3 | lld:pubmed |
| pubmed-article:12871940 | pubmed:volume | 278 | lld:pubmed |
| pubmed-article:12871940 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12871940 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12871940 | pubmed:pagination | 39155-65 | lld:pubmed |
| pubmed-article:12871940 | pubmed:dateRevised | 2003-11-14 | lld:pubmed |
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| pubmed-article:12871940 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12871940 | pubmed:articleTitle | Metabolic network control of oxidative phosphorylation: multiple roles of inorganic phosphate. | lld:pubmed |
| pubmed-article:12871940 | pubmed:affiliation | Laboratory of Cardiac Energetics, NHLBI, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA. | lld:pubmed |
| pubmed-article:12871940 | pubmed:publicationType | Journal Article | lld:pubmed |
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