pubmed-article:12871850 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:12871850 | lifeskim:mentions | umls-concept:C0024109 | lld:lifeskim |
pubmed-article:12871850 | lifeskim:mentions | umls-concept:C0020964 | lld:lifeskim |
pubmed-article:12871850 | lifeskim:mentions | umls-concept:C1158468 | lld:lifeskim |
pubmed-article:12871850 | lifeskim:mentions | umls-concept:C1514468 | lld:lifeskim |
pubmed-article:12871850 | lifeskim:mentions | umls-concept:C0038891 | lld:lifeskim |
pubmed-article:12871850 | lifeskim:mentions | umls-concept:C0127400 | lld:lifeskim |
pubmed-article:12871850 | lifeskim:mentions | umls-concept:C1363844 | lld:lifeskim |
pubmed-article:12871850 | pubmed:issue | 3 | lld:pubmed |
pubmed-article:12871850 | pubmed:dateCreated | 2004-2-18 | lld:pubmed |
pubmed-article:12871850 | pubmed:abstractText | Surfactant protein (SP)-D, a 43-kD multifunctional collagen-like lectin, is synthesized and secreted by the airway epithelium. SP-D knockout (SP-D [-/-]) mice exhibit an increase in the number and size of airway macrophages, peribronchiolar inflammation, increases in metalloproteinase activity, and development of emphysema. Nitric oxide (NO) is involved in a variety of signaling processes, and because altered NO metabolism has been observed in inflammation, we hypothesized that alterations in its metabolism would underlie the proinflammatory state observed in SP-D deficiency. Examination of the bronchial alveolar lavage (BAL) from SP-D (-/-) mice reveals a significant increase in protein and phospholipid content and total cell count. NO production and inducible NO synthase expression were increased in the BAL; however, there was a decline in S-nitrosothiol (SNO) content in the BAL and a loss of SNO immunoreactivity within the tissue. This decline in SNO was accompanied by an increase in nitrotyrosine staining. We conclude that inflammation that occurs in SP-D deficiency results in an increase in NO production and a shift in the chemistry and targets of NO. We speculate that the proinflammatory response due to SP-D deficiency results, in part, from a disruption of NO-mediated signaling within the innate immune system. | lld:pubmed |
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pubmed-article:12871850 | pubmed:language | eng | lld:pubmed |
pubmed-article:12871850 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:12871850 | pubmed:citationSubset | IM | lld:pubmed |
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pubmed-article:12871850 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:12871850 | pubmed:month | Mar | lld:pubmed |
pubmed-article:12871850 | pubmed:issn | 1044-1549 | lld:pubmed |
pubmed-article:12871850 | pubmed:author | pubmed-author:HawgoodSamuel... | lld:pubmed |
pubmed-article:12871850 | pubmed:author | pubmed-author:GowAndrew JAJ | lld:pubmed |
pubmed-article:12871850 | pubmed:author | pubmed-author:PoulainFranci... | lld:pubmed |
pubmed-article:12871850 | pubmed:author | pubmed-author:BeersMichael... | lld:pubmed |
pubmed-article:12871850 | pubmed:author | pubmed-author:AtochinaElena... | lld:pubmed |
pubmed-article:12871850 | pubmed:author | pubmed-author:DavisChristia... | lld:pubmed |
pubmed-article:12871850 | pubmed:author | pubmed-author:FusaroTrevorT | lld:pubmed |
pubmed-article:12871850 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:12871850 | pubmed:volume | 30 | lld:pubmed |
pubmed-article:12871850 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:12871850 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:12871850 | pubmed:pagination | 271-9 | lld:pubmed |
pubmed-article:12871850 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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pubmed-article:12871850 | pubmed:year | 2004 | lld:pubmed |
pubmed-article:12871850 | pubmed:articleTitle | Surfactant protein-D, a mediator of innate lung immunity, alters the products of nitric oxide metabolism. | lld:pubmed |
pubmed-article:12871850 | pubmed:affiliation | Pulmonary and Critical Care Division, University of Pennsylvania School of Medicine, Philadelphia, USA. | lld:pubmed |
pubmed-article:12871850 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:12871850 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
pubmed-article:12871850 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
entrez-gene:20390 | entrezgene:pubmed | pubmed-article:12871850 | lld:entrezgene |
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