| pubmed-article:12869023 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12869023 | lifeskim:mentions | umls-concept:C0032659 | lld:lifeskim |
| pubmed-article:12869023 | lifeskim:mentions | umls-concept:C0005532 | lld:lifeskim |
| pubmed-article:12869023 | lifeskim:mentions | umls-concept:C0026918 | lld:lifeskim |
| pubmed-article:12869023 | lifeskim:mentions | umls-concept:C0024398 | lld:lifeskim |
| pubmed-article:12869023 | lifeskim:mentions | umls-concept:C0024264 | lld:lifeskim |
| pubmed-article:12869023 | lifeskim:mentions | umls-concept:C0439662 | lld:lifeskim |
| pubmed-article:12869023 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:12869023 | pubmed:dateCreated | 2003-7-18 | lld:pubmed |
| pubmed-article:12869023 | pubmed:abstractText | Immune responses of lymphocyte populations during early phases of mycobacterial infection and reinfection have not been well characterized in humans. A non-human primate model of Mycobacterium bovis bacille Calmette-Guerin (BCG) infection was employed to characterize optimally the immune responses of mycobacteria-specific T cells. Primary BCG infection induced biphasic immune responses, characterized by initial lymphocytopenia and subsequent expansion of CD4+, CD8+ and gammadelta T cell populations in the blood, lymph nodes and the pulmonary compartment. The potency of detectable T cell immune responses appears to be influenced by the timing and route of infection as well as challenge doses of BCG organisms. Systemic BCG infection introduced by intravenous challenge induced a dose-dependent expansion of circulating CD4+, CD8+ and gammadelta T cells whereas, in the pulmonary compartment, the systemic infection resulted in a predominant increase in numbers of gammadelta T cells. In contrast, pulmonary exposure to BCG through the bronchial route induced detectable expansions of CD4+, CD8+ and gammadelta T cell populations in only the lung but not in the blood. A rapid recall expansion of these T cell populations was seen in the macaques reinfected intravenously and bronchially with BCG. The expanded alphabeta and gammadelta T cell populations exhibited their antigen specificity for mycobacterial peptides and non-peptide phospholigands, respectively. Finally, the major expansion of T cells was associated with a resolution of active BCG infection and reinfection. The patterns and kinetics of CD4+, CD8+ and gammadelta T cell immune responses during BCG infection might contribute to characterizing immune protection against tuberculosis and testing new tuberculosis vaccines in primates. | lld:pubmed |
| pubmed-article:12869023 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12869023 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12869023 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12869023 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12869023 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12869023 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12869023 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12869023 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12869023 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12869023 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12869023 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12869023 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12869023 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12869023 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12869023 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12869023 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12869023 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12869023 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12869023 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12869023 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12869023 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12869023 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12869023 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12869023 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12869023 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12869023 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12869023 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12869023 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12869023 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12869023 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12869023 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12869023 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12869023 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12869023 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12869023 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12869023 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12869023 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12869023 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12869023 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12869023 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12869023 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12869023 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12869023 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12869023 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12869023 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12869023 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12869023 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12869023 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12869023 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12869023 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12869023 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12869023 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12869023 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12869023 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12869023 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12869023 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12869023 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12869023 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12869023 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:12869023 | pubmed:issn | 0009-9104 | lld:pubmed |
| pubmed-article:12869023 | pubmed:author | pubmed-author:SimonMM | lld:pubmed |
| pubmed-article:12869023 | pubmed:author | pubmed-author:SehgalPP | lld:pubmed |
| pubmed-article:12869023 | pubmed:author | pubmed-author:LaoVV | lld:pubmed |
| pubmed-article:12869023 | pubmed:author | pubmed-author:ShenLL | lld:pubmed |
| pubmed-article:12869023 | pubmed:author | pubmed-author:ShenYY | lld:pubmed |
| pubmed-article:12869023 | pubmed:author | pubmed-author:ZhouDD | lld:pubmed |
| pubmed-article:12869023 | pubmed:author | pubmed-author:ChenZ WZW | lld:pubmed |
| pubmed-article:12869023 | pubmed:author | pubmed-author:LetvinN LNL | lld:pubmed |
| pubmed-article:12869023 | pubmed:author | pubmed-author:QiuLL | lld:pubmed |
| pubmed-article:12869023 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12869023 | pubmed:volume | 133 | lld:pubmed |
| pubmed-article:12869023 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12869023 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12869023 | pubmed:pagination | 182-92 | lld:pubmed |
| pubmed-article:12869023 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:12869023 | pubmed:meshHeading | pubmed-meshheading:12869023... | lld:pubmed |
| pubmed-article:12869023 | pubmed:meshHeading | pubmed-meshheading:12869023... | lld:pubmed |
| pubmed-article:12869023 | pubmed:meshHeading | pubmed-meshheading:12869023... | lld:pubmed |
| pubmed-article:12869023 | pubmed:meshHeading | pubmed-meshheading:12869023... | lld:pubmed |
| pubmed-article:12869023 | pubmed:meshHeading | pubmed-meshheading:12869023... | lld:pubmed |
| pubmed-article:12869023 | pubmed:meshHeading | pubmed-meshheading:12869023... | lld:pubmed |
| pubmed-article:12869023 | pubmed:meshHeading | pubmed-meshheading:12869023... | lld:pubmed |
| pubmed-article:12869023 | pubmed:meshHeading | pubmed-meshheading:12869023... | lld:pubmed |
| pubmed-article:12869023 | pubmed:meshHeading | pubmed-meshheading:12869023... | lld:pubmed |
| pubmed-article:12869023 | pubmed:meshHeading | pubmed-meshheading:12869023... | lld:pubmed |
| pubmed-article:12869023 | pubmed:meshHeading | pubmed-meshheading:12869023... | lld:pubmed |
| pubmed-article:12869023 | pubmed:meshHeading | pubmed-meshheading:12869023... | lld:pubmed |
| pubmed-article:12869023 | pubmed:meshHeading | pubmed-meshheading:12869023... | lld:pubmed |
| pubmed-article:12869023 | pubmed:meshHeading | pubmed-meshheading:12869023... | lld:pubmed |
| pubmed-article:12869023 | pubmed:year | 2003 | lld:pubmed |
