| pubmed-article:12868108 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12868108 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:12868108 | lifeskim:mentions | umls-concept:C0042784 | lld:lifeskim |
| pubmed-article:12868108 | lifeskim:mentions | umls-concept:C0439857 | lld:lifeskim |
| pubmed-article:12868108 | lifeskim:mentions | umls-concept:C0037638 | lld:lifeskim |
| pubmed-article:12868108 | lifeskim:mentions | umls-concept:C1521828 | lld:lifeskim |
| pubmed-article:12868108 | lifeskim:mentions | umls-concept:C1704711 | lld:lifeskim |
| pubmed-article:12868108 | lifeskim:mentions | umls-concept:C0185026 | lld:lifeskim |
| pubmed-article:12868108 | lifeskim:mentions | umls-concept:C2603343 | lld:lifeskim |
| pubmed-article:12868108 | lifeskim:mentions | umls-concept:C1880157 | lld:lifeskim |
| pubmed-article:12868108 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:12868108 | pubmed:dateCreated | 2003-7-17 | lld:pubmed |
| pubmed-article:12868108 | pubmed:abstractText | By using distributed computing techniques and a supercluster of more than 20,000 processors we simulated folding of a 20-residue Trp Cage miniprotein in atomistic detail with implicit GB/SA solvent at a variety of solvent viscosities (gamma). This allowed us to analyze the dependence of folding rates on viscosity. In particular, we focused on the low-viscosity regime (values below the viscosity of water). In accordance with Kramers' theory, we observe approximately linear dependence of the folding rate on 1/gamma for values from 1-10(-1)x that of water viscosity. However, for the regime between 10(-4)-10(-1)x that of water viscosity we observe power-law dependence of the form k approximately gamma(-1/5). These results suggest that estimating folding rates from molecular simulations run at low viscosity under the assumption of linear dependence of rate on inverse viscosity may lead to erroneous results. | lld:pubmed |
| pubmed-article:12868108 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12868108 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12868108 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12868108 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12868108 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12868108 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12868108 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12868108 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12868108 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12868108 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:12868108 | pubmed:issn | 0192-8651 | lld:pubmed |
| pubmed-article:12868108 | pubmed:author | pubmed-author:PandeVijayV | lld:pubmed |
| pubmed-article:12868108 | pubmed:author | pubmed-author:ZagrovicBojan... | lld:pubmed |
| pubmed-article:12868108 | pubmed:copyrightInfo | Copyright 2003 Wiley Periodicals, Inc. J Comput Chem 24: 1432-1436, 2003 | lld:pubmed |
| pubmed-article:12868108 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12868108 | pubmed:volume | 24 | lld:pubmed |
| pubmed-article:12868108 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12868108 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12868108 | pubmed:pagination | 1432-6 | lld:pubmed |
| pubmed-article:12868108 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:12868108 | pubmed:meshHeading | pubmed-meshheading:12868108... | lld:pubmed |
| pubmed-article:12868108 | pubmed:meshHeading | pubmed-meshheading:12868108... | lld:pubmed |
| pubmed-article:12868108 | pubmed:meshHeading | pubmed-meshheading:12868108... | lld:pubmed |
| pubmed-article:12868108 | pubmed:meshHeading | pubmed-meshheading:12868108... | lld:pubmed |
| pubmed-article:12868108 | pubmed:meshHeading | pubmed-meshheading:12868108... | lld:pubmed |
| pubmed-article:12868108 | pubmed:meshHeading | pubmed-meshheading:12868108... | lld:pubmed |
| pubmed-article:12868108 | pubmed:meshHeading | pubmed-meshheading:12868108... | lld:pubmed |
| pubmed-article:12868108 | pubmed:meshHeading | pubmed-meshheading:12868108... | lld:pubmed |
| pubmed-article:12868108 | pubmed:meshHeading | pubmed-meshheading:12868108... | lld:pubmed |
| pubmed-article:12868108 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12868108 | pubmed:articleTitle | Solvent viscosity dependence of the folding rate of a small protein: distributed computing study. | lld:pubmed |
| pubmed-article:12868108 | pubmed:affiliation | Biophysics Program and Department of Chemistry, Stanford University, Stanford, CA 94305, USA. | lld:pubmed |
| pubmed-article:12868108 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12868108 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:12868108 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:12868108 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12868108 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12868108 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12868108 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12868108 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12868108 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12868108 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12868108 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12868108 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12868108 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12868108 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12868108 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12868108 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12868108 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12868108 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12868108 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12868108 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12868108 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12868108 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12868108 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12868108 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12868108 | lld:pubmed |
