| pubmed-article:12867998 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12867998 | lifeskim:mentions | umls-concept:C1257751 | lld:lifeskim |
| pubmed-article:12867998 | lifeskim:mentions | umls-concept:C0796355 | lld:lifeskim |
| pubmed-article:12867998 | lifeskim:mentions | umls-concept:C1330957 | lld:lifeskim |
| pubmed-article:12867998 | lifeskim:mentions | umls-concept:C0040648 | lld:lifeskim |
| pubmed-article:12867998 | lifeskim:mentions | umls-concept:C0378781 | lld:lifeskim |
| pubmed-article:12867998 | lifeskim:mentions | umls-concept:C1416745 | lld:lifeskim |
| pubmed-article:12867998 | lifeskim:mentions | umls-concept:C1425354 | lld:lifeskim |
| pubmed-article:12867998 | lifeskim:mentions | umls-concept:C0596311 | lld:lifeskim |
| pubmed-article:12867998 | lifeskim:mentions | umls-concept:C2587213 | lld:lifeskim |
| pubmed-article:12867998 | lifeskim:mentions | umls-concept:C0033268 | lld:lifeskim |
| pubmed-article:12867998 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:12867998 | pubmed:dateCreated | 2003-7-17 | lld:pubmed |
| pubmed-article:12867998 | pubmed:abstractText | SCL/Tal-1 is a helix-loop-helix (HLH) transcription factor required for blood cell development, whose abnormal expression is responsible for induction of T-cell acute lymphoblastic leukemia. We show here that SCL/Tal-1 is a key target of caspases in developing erythroblasts. SCL/Tal-1 degradation occurred rapidly after caspase activation and preceded the cleavage of the major erythroid transcription factor GATA-1. Expression of a caspase-resistant SCL/Tal-1 in erythroid progenitors was able to prevent amplification of caspase activation, GATA-1 degradation and impaired erythropoiesis induced by growth factor deprivation or death receptor triggering. The potent proerythropoietic activity of uncleavable SCL/Tal-1 was clearly evident in the absence of erythropoietin, a condition that did not allow survival of normal erythroid cells or expansion of erythroblasts expressing caspase-resistant GATA-1. In the absence of erythropoietin, cells expressing caspase-resistant SCL/Tal-1 maintain high levels of Bcl-X(L), which inhibits amplification of the caspase cascade and mediates protection from apoptosis. Thus, SCL/TAL-1 is a survival factor for erythroid cells, whereas caspase-mediated cleavage of SCL/Tal-1 results in amplification of caspase activation, GATA-1 degradation and impaired erythropoiesis. | lld:pubmed |
| pubmed-article:12867998 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12867998 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12867998 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12867998 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12867998 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12867998 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12867998 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12867998 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12867998 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12867998 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12867998 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12867998 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12867998 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12867998 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12867998 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12867998 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12867998 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12867998 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12867998 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12867998 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12867998 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12867998 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12867998 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12867998 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12867998 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12867998 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12867998 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12867998 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12867998 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12867998 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12867998 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12867998 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12867998 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12867998 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:12867998 | pubmed:issn | 1350-9047 | lld:pubmed |
| pubmed-article:12867998 | pubmed:author | pubmed-author:TestaUU | lld:pubmed |
| pubmed-article:12867998 | pubmed:author | pubmed-author:PeschleCC | lld:pubmed |
| pubmed-article:12867998 | pubmed:author | pubmed-author:CondorelliGG | lld:pubmed |
| pubmed-article:12867998 | pubmed:author | pubmed-author:MarianiGG | lld:pubmed |
| pubmed-article:12867998 | pubmed:author | pubmed-author:FellsPP | lld:pubmed |
| pubmed-article:12867998 | pubmed:author | pubmed-author:PelosiEE | lld:pubmed |
| pubmed-article:12867998 | pubmed:author | pubmed-author:De MariaRR | lld:pubmed |
| pubmed-article:12867998 | pubmed:author | pubmed-author:AlnemriE SES | lld:pubmed |
| pubmed-article:12867998 | pubmed:author | pubmed-author:ZeunerAA | lld:pubmed |
| pubmed-article:12867998 | pubmed:author | pubmed-author:SrinivasulaS... | lld:pubmed |
| pubmed-article:12867998 | pubmed:author | pubmed-author:EramoAA | lld:pubmed |
| pubmed-article:12867998 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12867998 | pubmed:volume | 10 | lld:pubmed |
| pubmed-article:12867998 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12867998 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12867998 | pubmed:pagination | 905-13 | lld:pubmed |
| pubmed-article:12867998 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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