| pubmed-article:12858171 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12858171 | lifeskim:mentions | umls-concept:C0035647 | lld:lifeskim |
| pubmed-article:12858171 | lifeskim:mentions | umls-concept:C0024501 | lld:lifeskim |
| pubmed-article:12858171 | lifeskim:mentions | umls-concept:C0039062 | lld:lifeskim |
| pubmed-article:12858171 | lifeskim:mentions | umls-concept:C0034790 | lld:lifeskim |
| pubmed-article:12858171 | lifeskim:mentions | umls-concept:C1514762 | lld:lifeskim |
| pubmed-article:12858171 | lifeskim:mentions | umls-concept:C0549178 | lld:lifeskim |
| pubmed-article:12858171 | lifeskim:mentions | umls-concept:C1546857 | lld:lifeskim |
| pubmed-article:12858171 | lifeskim:mentions | umls-concept:C1556066 | lld:lifeskim |
| pubmed-article:12858171 | lifeskim:mentions | umls-concept:C1619636 | lld:lifeskim |
| pubmed-article:12858171 | lifeskim:mentions | umls-concept:C1514873 | lld:lifeskim |
| pubmed-article:12858171 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:12858171 | pubmed:dateCreated | 2003-7-30 | lld:pubmed |
| pubmed-article:12858171 | pubmed:abstractText | Although signals through the T cell receptor (TCR) are essential for the initiation of T helper cell activation, it is unclear what function such signals have during the prolonged T cell-antigen-presenting cell contact. Here we simultaneously tracked TCR-CD3 complex and phosphoinositide 3-kinase activity in single T cells using three-dimensional video microscopy. Despite rapid internalization of most of the TCR-CD3, TCR-dependent signaling was still evident up to 10 h after conjugate formation. Blocking this interaction caused dissolution of the synapse and proportional reductions in interleukin 2 production and cellular proliferation. Thus TCR signaling persists for hours, has a cumulative effect and is necessary for the maintenance of the immunological synapse. | lld:pubmed |
| pubmed-article:12858171 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12858171 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12858171 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12858171 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12858171 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12858171 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12858171 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12858171 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12858171 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12858171 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:12858171 | pubmed:issn | 1529-2908 | lld:pubmed |
| pubmed-article:12858171 | pubmed:author | pubmed-author:SumenCenkC | lld:pubmed |
| pubmed-article:12858171 | pubmed:author | pubmed-author:DavisMark MMM | lld:pubmed |
| pubmed-article:12858171 | pubmed:author | pubmed-author:GleimerMichae... | lld:pubmed |
| pubmed-article:12858171 | pubmed:author | pubmed-author:HuppaJohannes... | lld:pubmed |
| pubmed-article:12858171 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12858171 | pubmed:volume | 4 | lld:pubmed |
| pubmed-article:12858171 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12858171 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12858171 | pubmed:pagination | 749-55 | lld:pubmed |
| pubmed-article:12858171 | pubmed:dateRevised | 2007-11-8 | lld:pubmed |
| pubmed-article:12858171 | pubmed:meshHeading | pubmed-meshheading:12858171... | lld:pubmed |
| pubmed-article:12858171 | pubmed:meshHeading | pubmed-meshheading:12858171... | lld:pubmed |
| pubmed-article:12858171 | pubmed:meshHeading | pubmed-meshheading:12858171... | lld:pubmed |
| pubmed-article:12858171 | pubmed:meshHeading | pubmed-meshheading:12858171... | lld:pubmed |
| pubmed-article:12858171 | pubmed:meshHeading | pubmed-meshheading:12858171... | lld:pubmed |
| pubmed-article:12858171 | pubmed:meshHeading | pubmed-meshheading:12858171... | lld:pubmed |
| pubmed-article:12858171 | pubmed:meshHeading | pubmed-meshheading:12858171... | lld:pubmed |
| pubmed-article:12858171 | pubmed:meshHeading | pubmed-meshheading:12858171... | lld:pubmed |
| pubmed-article:12858171 | pubmed:meshHeading | pubmed-meshheading:12858171... | lld:pubmed |
| pubmed-article:12858171 | pubmed:meshHeading | pubmed-meshheading:12858171... | lld:pubmed |
| pubmed-article:12858171 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12858171 | pubmed:articleTitle | Continuous T cell receptor signaling required for synapse maintenance and full effector potential. | lld:pubmed |
| pubmed-article:12858171 | pubmed:affiliation | Stanford University School of Medicine, Department of Microbiology and Immunology, and Howard Hughes Medical Institute, Beckman Center B221, 279 Campus Drive, Stanford, California 94305, USA. | lld:pubmed |
| pubmed-article:12858171 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12858171 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:12858171 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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