| pubmed-article:12858047 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12858047 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:12858047 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:12858047 | lifeskim:mentions | umls-concept:C0206116 | lld:lifeskim |
| pubmed-article:12858047 | lifeskim:mentions | umls-concept:C0162638 | lld:lifeskim |
| pubmed-article:12858047 | lifeskim:mentions | umls-concept:C1882598 | lld:lifeskim |
| pubmed-article:12858047 | lifeskim:mentions | umls-concept:C1510411 | lld:lifeskim |
| pubmed-article:12858047 | lifeskim:mentions | umls-concept:C0013081 | lld:lifeskim |
| pubmed-article:12858047 | lifeskim:mentions | umls-concept:C0018270 | lld:lifeskim |
| pubmed-article:12858047 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:12858047 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:12858047 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:12858047 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:12858047 | pubmed:dateCreated | 2003-7-14 | lld:pubmed |
| pubmed-article:12858047 | pubmed:abstractText | Transforming growth factor (TGF)-beta1 is a key regulator of brain response to injury and inflammation. It exerts anti-inflammatory roles by inhibiting microglial proliferation and free radical induction. TGF-beta1 is known to induce apoptotic cell death of microglia in a Bcl-2-independent pathway. The purpose of this study was to examine detailed mechanisms of TGF-beta1-induced microglial apoptosis. Assays for cell viability and DNA fragmentation demonstrated that TGF-beta1 induced apoptotic cell death in primary rat microglial cultures. Reverse transcription (RT)-PCR analysis showed that primary microglial cells expressed mRNAs for rat inhibitor-of-apoptosis protein (RIAP)-1 and RIAP-3 under normal culture conditions and that treatment with TGF-beta1 resulted in a significant reduction in the amounts of RIAP-1 and RIAP-3 mRNAs. Because IAPs are potent suppressor of apoptotic cell death, decrease in IAP expression might provide an important regulatory function in TGF-beta1-mediated microglial death and in attenuation of excessive microglial activation in pathological conditions. | lld:pubmed |
| pubmed-article:12858047 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12858047 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12858047 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12858047 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12858047 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12858047 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12858047 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12858047 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12858047 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12858047 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12858047 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12858047 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12858047 | pubmed:month | May | lld:pubmed |
| pubmed-article:12858047 | pubmed:issn | 0959-4965 | lld:pubmed |
| pubmed-article:12858047 | pubmed:author | pubmed-author:YunSu-JinSJ | lld:pubmed |
| pubmed-article:12858047 | pubmed:author | pubmed-author:LeeEunjoo HEH | lld:pubmed |
| pubmed-article:12858047 | pubmed:author | pubmed-author:KimMi-OkMO | lld:pubmed |
| pubmed-article:12858047 | pubmed:author | pubmed-author:JungBomiB | lld:pubmed |
| pubmed-article:12858047 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12858047 | pubmed:day | 6 | lld:pubmed |
| pubmed-article:12858047 | pubmed:volume | 14 | lld:pubmed |
| pubmed-article:12858047 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12858047 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12858047 | pubmed:pagination | 857-60 | lld:pubmed |
| pubmed-article:12858047 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:12858047 | pubmed:meshHeading | pubmed-meshheading:12858047... | lld:pubmed |
| pubmed-article:12858047 | pubmed:meshHeading | pubmed-meshheading:12858047... | lld:pubmed |
| pubmed-article:12858047 | pubmed:meshHeading | pubmed-meshheading:12858047... | lld:pubmed |
| pubmed-article:12858047 | pubmed:meshHeading | pubmed-meshheading:12858047... | lld:pubmed |
| pubmed-article:12858047 | pubmed:meshHeading | pubmed-meshheading:12858047... | lld:pubmed |
| pubmed-article:12858047 | pubmed:meshHeading | pubmed-meshheading:12858047... | lld:pubmed |
| pubmed-article:12858047 | pubmed:meshHeading | pubmed-meshheading:12858047... | lld:pubmed |
| pubmed-article:12858047 | pubmed:meshHeading | pubmed-meshheading:12858047... | lld:pubmed |
| pubmed-article:12858047 | pubmed:meshHeading | pubmed-meshheading:12858047... | lld:pubmed |
| pubmed-article:12858047 | pubmed:meshHeading | pubmed-meshheading:12858047... | lld:pubmed |
| pubmed-article:12858047 | pubmed:meshHeading | pubmed-meshheading:12858047... | lld:pubmed |
| pubmed-article:12858047 | pubmed:meshHeading | pubmed-meshheading:12858047... | lld:pubmed |
| pubmed-article:12858047 | pubmed:meshHeading | pubmed-meshheading:12858047... | lld:pubmed |
| pubmed-article:12858047 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12858047 | pubmed:articleTitle | Down-regulation of the expression of rat inhibitor-of-apoptosis protein-1 and -3 during transforming growth factor-beta1-mediated apoptosis in rat brain microglia. | lld:pubmed |
| pubmed-article:12858047 | pubmed:affiliation | Graduate School of East-West Medical Science, Kyung Hee University, Yong-In 499-701, Korea. | lld:pubmed |
| pubmed-article:12858047 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12858047 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:63879 | entrezgene:pubmed | pubmed-article:12858047 | lld:entrezgene |
| entrez-gene:78971 | entrezgene:pubmed | pubmed-article:12858047 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:12858047 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:12858047 | lld:entrezgene |
