| pubmed-article:12856332 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12856332 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:12856332 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:12856332 | lifeskim:mentions | umls-concept:C0026336 | lld:lifeskim |
| pubmed-article:12856332 | lifeskim:mentions | umls-concept:C0083031 | lld:lifeskim |
| pubmed-article:12856332 | lifeskim:mentions | umls-concept:C0262950 | lld:lifeskim |
| pubmed-article:12856332 | lifeskim:mentions | umls-concept:C0029433 | lld:lifeskim |
| pubmed-article:12856332 | lifeskim:mentions | umls-concept:C0574895 | lld:lifeskim |
| pubmed-article:12856332 | lifeskim:mentions | umls-concept:C1551336 | lld:lifeskim |
| pubmed-article:12856332 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:12856332 | pubmed:dateCreated | 2003-7-14 | lld:pubmed |
| pubmed-article:12856332 | pubmed:abstractText | We previously demonstrated that recombinant human interleukin-11 (rHuIL-11) induced osteoblast differentiation of C3H10T1/2 progenitor cells and also acted synergistically with recombinant human bone morphogenetic protein-2 (rHuBMP-2) in performing the same function. In this study, we investigated the effect of rHuIL-11 and rHuBMP-2 on bone formation in a rat ectopic model. When placed in rats, implants consisting of polymer-coated gelatin sponges containing various concentrations of rHuBMP-2 showed a dose-dependent increase in calcium content. This was confirmed by radiographic analysis of the implants. Although implants containing rHuIL-11 alone did not accumulate calcium, implants containing a combination of rHuBMP-2 and rHuIL-11 had significantly higher calcium levels than those containing rHuBMP-2 alone. This increase was rHuIL-11 dose dependent. The synergistic effect of 20 micrograms rHuIL-11 and 6 micrograms rHuBMP-2 on bone formation was estimated to be 1 week in advance of that of 6 micrograms rHuBMP-2 alone. Histologic examination revealed that the combination of rHuIL-11 and rHuBMP-2 caused spindle cells to accumulate around implants and induced cell infiltration into implants. Bone formation occurred faster in implants with the combination of rHuIL-11 and rHuBMP-2 compared with rHuBMP-2 alone. These results suggest that rHuIL-11 acts synergistically with rHuBMP-2 to more rapidly stimulate bone formation compared with rHuBMP-2 alone. This novel combined therapy may be of great clinical benefit in bone healing. | lld:pubmed |
| pubmed-article:12856332 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12856332 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12856332 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12856332 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12856332 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12856332 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12856332 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12856332 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12856332 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12856332 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12856332 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12856332 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12856332 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12856332 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:12856332 | pubmed:issn | 1079-9907 | lld:pubmed |
| pubmed-article:12856332 | pubmed:author | pubmed-author:SaitohMinoriM | lld:pubmed |
| pubmed-article:12856332 | pubmed:author | pubmed-author:SugaKazutakaK | lld:pubmed |
| pubmed-article:12856332 | pubmed:author | pubmed-author:YasudaShuheiS | lld:pubmed |
| pubmed-article:12856332 | pubmed:author | pubmed-author:MiyataKeijiK | lld:pubmed |
| pubmed-article:12856332 | pubmed:author | pubmed-author:KakuSeijiS | lld:pubmed |
| pubmed-article:12856332 | pubmed:author | pubmed-author:KokuboSatoshi... | lld:pubmed |
| pubmed-article:12856332 | pubmed:author | pubmed-author:FukushimaShin... | lld:pubmed |
| pubmed-article:12856332 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12856332 | pubmed:volume | 23 | lld:pubmed |
| pubmed-article:12856332 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12856332 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12856332 | pubmed:pagination | 203-7 | lld:pubmed |
| pubmed-article:12856332 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:12856332 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12856332 | pubmed:articleTitle | Interleukin-11 acts synergistically with bone morphogenetic protein-2 to accelerate bone formation in a rat ectopic model. | lld:pubmed |
| pubmed-article:12856332 | pubmed:affiliation | Pharmacology Laboratories, Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co., Ltd., Tsukuba, Ibaraki, Japan. suga.kazutaka@yamanouchi.co.jp | lld:pubmed |
| pubmed-article:12856332 | pubmed:publicationType | Journal Article | lld:pubmed |
| entrez-gene:650 | entrezgene:pubmed | pubmed-article:12856332 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:12856332 | lld:entrezgene |
