Linked Life Data

12855618

Source:http://linkedlifedata.com/resource/pubmed/id/12855618

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pubmed-article:12855618pubmed:abstractTextEpidermal growth factor receptor (EGFR) appears to play an important role in the pathogenesis of colorectal cancer. We have performed a Phase I/II study of the EGFR tyrosine kinase inhibitor ZD1839 in metastatic colorectal cancer patients in which serial biopsies were taken pre- and posttreatment to assess biological activity. Experimental Design: Paired biopsies were obtained from colorectal cancer patients before and after treatment. Proliferation and apoptosis were assessed using Ki67 immunohistochemistry and terminal deoxynucleotidyl transferase-mediated nick end labeling assays, respectively. Immunohistochemistry for EGFR, activated EGFR, phosphorylated Akt, phosphorylated ERK, p27(Kip1), and beta-catenin was also performed.lld:pubmed
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pubmed-article:12855618pubmed:articleTitleA pharmacodynamic study of the epidermal growth factor receptor tyrosine kinase inhibitor ZD1839 in metastatic colorectal cancer patients.lld:pubmed
pubmed-article:12855618pubmed:affiliationOttawa Regional Cancer Centre, Ottawa, Ontario, K1H 1C4 Canada.lld:pubmed
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pubmed-article:12855618pubmed:publicationTypeClinical Triallld:pubmed
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