| pubmed-article:12852482 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12852482 | lifeskim:mentions | umls-concept:C0034493 | lld:lifeskim |
| pubmed-article:12852482 | lifeskim:mentions | umls-concept:C0004057 | lld:lifeskim |
| pubmed-article:12852482 | lifeskim:mentions | umls-concept:C0242290 | lld:lifeskim |
| pubmed-article:12852482 | lifeskim:mentions | umls-concept:C0600688 | lld:lifeskim |
| pubmed-article:12852482 | lifeskim:mentions | umls-concept:C0678723 | lld:lifeskim |
| pubmed-article:12852482 | lifeskim:mentions | umls-concept:C1527148 | lld:lifeskim |
| pubmed-article:12852482 | lifeskim:mentions | umls-concept:C1707455 | lld:lifeskim |
| pubmed-article:12852482 | lifeskim:mentions | umls-concept:C1521801 | lld:lifeskim |
| pubmed-article:12852482 | lifeskim:mentions | umls-concept:C0557702 | lld:lifeskim |
| pubmed-article:12852482 | lifeskim:mentions | umls-concept:C0332324 | lld:lifeskim |
| pubmed-article:12852482 | lifeskim:mentions | umls-concept:C0458003 | lld:lifeskim |
| pubmed-article:12852482 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:12852482 | pubmed:dateCreated | 2003-7-10 | lld:pubmed |
| pubmed-article:12852482 | pubmed:abstractText | A review of the nonsteroidal anti-inflammatory drug (NSAID) literature suggested occurrences of low-level incidences of cardiovascular and midline defects in rabbit fetuses exposed in utero. Aspirin (acetylsalicylic acid, ASA) is a widely used NSAID that irreversibly inhibits cyclooxygenases (COXs) 1 and 2. ASA has been studied extensively in rats and has consistently increased low-incidence cardiovascular malformations and defects in midline closure. The objectives of the current study were to comprehensively define the developmental toxicology profile of ASA in rabbits by using a dosing paradigm encompassing the period of organogenesis and to test the hypothesis that maternal gastrointestinal toxicity after repeated dose administrations hampers the detection of low-incidence malformations with ASA in rabbits by limiting ASA administration to sensitive windows for cardiovascular development and midline closure. | lld:pubmed |
| pubmed-article:12852482 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12852482 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12852482 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12852482 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12852482 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12852482 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12852482 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12852482 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:12852482 | pubmed:issn | 1542-9733 | lld:pubmed |
| pubmed-article:12852482 | pubmed:author | pubmed-author:GuptaUU | lld:pubmed |
| pubmed-article:12852482 | pubmed:author | pubmed-author:HurttM EME | lld:pubmed |
| pubmed-article:12852482 | pubmed:author | pubmed-author:TassinariM... | lld:pubmed |
| pubmed-article:12852482 | pubmed:author | pubmed-author:CookJ CJC | lld:pubmed |
| pubmed-article:12852482 | pubmed:author | pubmed-author:CapponG DGD | lld:pubmed |
| pubmed-article:12852482 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12852482 | pubmed:volume | 68 | lld:pubmed |
| pubmed-article:12852482 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12852482 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12852482 | pubmed:pagination | 38-46 | lld:pubmed |
| pubmed-article:12852482 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:12852482 | pubmed:meshHeading | pubmed-meshheading:12852482... | lld:pubmed |
| pubmed-article:12852482 | pubmed:meshHeading | pubmed-meshheading:12852482... | lld:pubmed |
| pubmed-article:12852482 | pubmed:meshHeading | pubmed-meshheading:12852482... | lld:pubmed |
| pubmed-article:12852482 | pubmed:meshHeading | pubmed-meshheading:12852482... | lld:pubmed |
| pubmed-article:12852482 | pubmed:meshHeading | pubmed-meshheading:12852482... | lld:pubmed |
| pubmed-article:12852482 | pubmed:meshHeading | pubmed-meshheading:12852482... | lld:pubmed |
| pubmed-article:12852482 | pubmed:meshHeading | pubmed-meshheading:12852482... | lld:pubmed |
| pubmed-article:12852482 | pubmed:meshHeading | pubmed-meshheading:12852482... | lld:pubmed |
| pubmed-article:12852482 | pubmed:meshHeading | pubmed-meshheading:12852482... | lld:pubmed |
| pubmed-article:12852482 | pubmed:meshHeading | pubmed-meshheading:12852482... | lld:pubmed |
| pubmed-article:12852482 | pubmed:meshHeading | pubmed-meshheading:12852482... | lld:pubmed |
| pubmed-article:12852482 | pubmed:meshHeading | pubmed-meshheading:12852482... | lld:pubmed |
| pubmed-article:12852482 | pubmed:meshHeading | pubmed-meshheading:12852482... | lld:pubmed |
| pubmed-article:12852482 | pubmed:meshHeading | pubmed-meshheading:12852482... | lld:pubmed |
| pubmed-article:12852482 | pubmed:meshHeading | pubmed-meshheading:12852482... | lld:pubmed |
| pubmed-article:12852482 | pubmed:meshHeading | pubmed-meshheading:12852482... | lld:pubmed |
| pubmed-article:12852482 | pubmed:meshHeading | pubmed-meshheading:12852482... | lld:pubmed |
| pubmed-article:12852482 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12852482 | pubmed:articleTitle | Comparison of the developmental toxicity of aspirin in rabbits when administered throughout organogenesis or during sensitive windows of development. | lld:pubmed |
| pubmed-article:12852482 | pubmed:affiliation | Pfizer Global Research & Development, Groton, Connecticut 06340, USA. gregg_d_cappon@groton.pfizer.com | lld:pubmed |
| pubmed-article:12852482 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12852482 | pubmed:publicationType | Comparative Study | lld:pubmed |
