| pubmed-article:12851300 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12851300 | lifeskim:mentions | umls-concept:C0668289 | lld:lifeskim |
| pubmed-article:12851300 | lifeskim:mentions | umls-concept:C0015219 | lld:lifeskim |
| pubmed-article:12851300 | lifeskim:mentions | umls-concept:C0678594 | lld:lifeskim |
| pubmed-article:12851300 | lifeskim:mentions | umls-concept:C1705810 | lld:lifeskim |
| pubmed-article:12851300 | pubmed:dateCreated | 2003-7-9 | lld:pubmed |
| pubmed-article:12851300 | pubmed:abstractText | The melanocortin (MC)-4 receptor participates in regulating body weight homeostasis. We demonstrated early that acute blockage of the MC-4 receptor increases food intake and relieves anorexic conditions in rats. Our recent studies show that 4-week chronic blockage of the MC-4 receptor leads to robust increases in food intake and development of obesity, whereas stimulation of the receptor leads to anorexia. Interestingly, the food conversion ratio was clearly increased by MC-4 receptor blockage, whereas it was decreased in agonist-treated rats in a transient manner. Chronic infusion of an agonist caused a transient increase in oxygen consumption. Our studies also show that the MC-4 receptor plays a role in luteinizing hormone and prolactin surges in female rats. The MC-4 receptor has a role in mediating the effects of leptin on these surges. The phylogenetic relation of the MC-4 receptor to other GPCRs in the human genome was determined. The three-dimensional structure of the protein was studied by construction of a high-affinity zinc binding site between the helices, using two histidine residues facing each other. We also cloned the MC-4 receptor from evolutionary important species and showed by chromosomal mapping a conserved synteny between humans and zebrafish. The MC-4 receptor has been remarkably conserved in structure and pharmacology for more than 400 million years, implying that the receptor participated in vital physiological functions early in vertebrate evolution. | lld:pubmed |
| pubmed-article:12851300 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12851300 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12851300 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12851300 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12851300 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12851300 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12851300 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12851300 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12851300 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:12851300 | pubmed:issn | 0077-8923 | lld:pubmed |
| pubmed-article:12851300 | pubmed:author | pubmed-author:WatanobeHajim... | lld:pubmed |
| pubmed-article:12851300 | pubmed:author | pubmed-author:SchiöthHelgi... | lld:pubmed |
| pubmed-article:12851300 | pubmed:author | pubmed-author:FredrikssonRo... | lld:pubmed |
| pubmed-article:12851300 | pubmed:author | pubmed-author:RingholmAneta... | lld:pubmed |
| pubmed-article:12851300 | pubmed:author | pubmed-author:VergoniAnna... | lld:pubmed |
| pubmed-article:12851300 | pubmed:author | pubmed-author:LagerströmMal... | lld:pubmed |
| pubmed-article:12851300 | pubmed:author | pubmed-author:KlovinsJanisJ | lld:pubmed |
| pubmed-article:12851300 | pubmed:author | pubmed-author:JonssonLogiL | lld:pubmed |
| pubmed-article:12851300 | pubmed:author | pubmed-author:Skarphedinsso... | lld:pubmed |
| pubmed-article:12851300 | pubmed:author | pubmed-author:SkuladottirGu... | lld:pubmed |
| pubmed-article:12851300 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12851300 | pubmed:volume | 994 | lld:pubmed |
| pubmed-article:12851300 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12851300 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12851300 | pubmed:pagination | 74-83 | lld:pubmed |
| pubmed-article:12851300 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:12851300 | pubmed:meshHeading | pubmed-meshheading:12851300... | lld:pubmed |
| pubmed-article:12851300 | pubmed:meshHeading | pubmed-meshheading:12851300... | lld:pubmed |
| pubmed-article:12851300 | pubmed:meshHeading | pubmed-meshheading:12851300... | lld:pubmed |
| pubmed-article:12851300 | pubmed:meshHeading | pubmed-meshheading:12851300... | lld:pubmed |
| pubmed-article:12851300 | pubmed:meshHeading | pubmed-meshheading:12851300... | lld:pubmed |
| pubmed-article:12851300 | pubmed:meshHeading | pubmed-meshheading:12851300... | lld:pubmed |
| pubmed-article:12851300 | pubmed:meshHeading | pubmed-meshheading:12851300... | lld:pubmed |
| pubmed-article:12851300 | pubmed:meshHeading | pubmed-meshheading:12851300... | lld:pubmed |
| pubmed-article:12851300 | pubmed:meshHeading | pubmed-meshheading:12851300... | lld:pubmed |
| pubmed-article:12851300 | pubmed:meshHeading | pubmed-meshheading:12851300... | lld:pubmed |
| pubmed-article:12851300 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12851300 | pubmed:articleTitle | Functional role, structure, and evolution of the melanocortin-4 receptor. | lld:pubmed |
| pubmed-article:12851300 | pubmed:affiliation | Department of Neuroscience, Uppsala University, BMC, 751 24, Uppsala, Sweden. helgis@bmc.uu.se | lld:pubmed |
| pubmed-article:12851300 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12851300 | pubmed:publicationType | Review | lld:pubmed |
| pubmed-article:12851300 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:286833 | entrezgene:pubmed | pubmed-article:12851300 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12851300 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12851300 | lld:pubmed |
