| pubmed-article:12843744 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12843744 | lifeskim:mentions | umls-concept:C0021311 | lld:lifeskim |
| pubmed-article:12843744 | lifeskim:mentions | umls-concept:C0162643 | lld:lifeskim |
| pubmed-article:12843744 | lifeskim:mentions | umls-concept:C0332281 | lld:lifeskim |
| pubmed-article:12843744 | lifeskim:mentions | umls-concept:C0814470 | lld:lifeskim |
| pubmed-article:12843744 | lifeskim:mentions | umls-concept:C0162735 | lld:lifeskim |
| pubmed-article:12843744 | lifeskim:mentions | umls-concept:C0449560 | lld:lifeskim |
| pubmed-article:12843744 | lifeskim:mentions | umls-concept:C0449774 | lld:lifeskim |
| pubmed-article:12843744 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:12843744 | pubmed:dateCreated | 2003-7-4 | lld:pubmed |
| pubmed-article:12843744 | pubmed:abstractText | An increasing number of HIV-1-infected patients living in developing countries now have access to antiretroviral drugs. Information regarding the drug-resistant mutations of non-B subtype HIV-1 remains limited, however. The authors cross-sectionally compared patterns of the drug-resistant point mutations in patients infected with either subtype B or CRF01_AE (subtype E) among patients who acquired HIV by sexual transmission in Japan. Protease sequence data were available from 216 patients with a detectable level of RNA copies in plasma. Based on phylogenetic analysis of the protease and the C2V3 regions, 162 subtype B and 45 CRF01_AE cases were identified; 82 subtype B and 24 CRF01_AE patients had a treatment failure with nucleoside reverse transcriptase inhibitors; and 69 subtype B and 19 CRF01_AE patients had a treatment failure with a protease inhibitor. Antiretroviral drug history was similar in subtype B-infected and CRF01_AE-infected patients. The mutations T69N and V75M in reverse transcriptase and L10F, K20I, L33I, and N88S in protease were seen more frequently in patients infected with CRF01_AE than in patients with subtype B. The mutations, D30N, A71V, and N88D were found exclusively in patients with subtype B. Most of the characteristic mutation patterns were associated with a history of receiving nelfinavir. The pattern of drug resistance mutations differs between the subtypes. Data derived from subtype B drug-resistant genotypes may not always be applicable to non-B subtypes. | lld:pubmed |
| pubmed-article:12843744 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12843744 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12843744 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:12843744 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12843744 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:12843744 | pubmed:issn | 1525-4135 | lld:pubmed |
| pubmed-article:12843744 | pubmed:author | pubmed-author:SugiuraWataru... | lld:pubmed |
| pubmed-article:12843744 | pubmed:author | pubmed-author:MatsudaMasaka... | lld:pubmed |
| pubmed-article:12843744 | pubmed:author | pubmed-author:YamadaKaneoK | lld:pubmed |
| pubmed-article:12843744 | pubmed:author | pubmed-author:AriyoshiKoyoK | lld:pubmed |
| pubmed-article:12843744 | pubmed:author | pubmed-author:MiuraHidekaH | lld:pubmed |
| pubmed-article:12843744 | pubmed:author | pubmed-author:TateishiSachi... | lld:pubmed |
| pubmed-article:12843744 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12843744 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:12843744 | pubmed:volume | 33 | lld:pubmed |
| pubmed-article:12843744 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12843744 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12843744 | pubmed:pagination | 336-42 | lld:pubmed |
| pubmed-article:12843744 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:12843744 | pubmed:meshHeading | pubmed-meshheading:12843744... | lld:pubmed |
| pubmed-article:12843744 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12843744 | pubmed:articleTitle | Patterns of point mutations associated with antiretroviral drug treatment failure in CRF01_AE (subtype E) infection differ from subtype B infection. | lld:pubmed |
| pubmed-article:12843744 | pubmed:affiliation | AIDS Research Center, National Institute of Infectious Diseases, Tokyo, Japan. | lld:pubmed |
| pubmed-article:12843744 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12843744 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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