| pubmed-article:12842131 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12842131 | lifeskim:mentions | umls-concept:C0001554 | lld:lifeskim |
| pubmed-article:12842131 | lifeskim:mentions | umls-concept:C0085828 | lld:lifeskim |
| pubmed-article:12842131 | lifeskim:mentions | umls-concept:C1882598 | lld:lifeskim |
| pubmed-article:12842131 | lifeskim:mentions | umls-concept:C0002600 | lld:lifeskim |
| pubmed-article:12842131 | lifeskim:mentions | umls-concept:C0003289 | lld:lifeskim |
| pubmed-article:12842131 | lifeskim:mentions | umls-concept:C0040648 | lld:lifeskim |
| pubmed-article:12842131 | lifeskim:mentions | umls-concept:C0107103 | lld:lifeskim |
| pubmed-article:12842131 | lifeskim:mentions | umls-concept:C1148673 | lld:lifeskim |
| pubmed-article:12842131 | lifeskim:mentions | umls-concept:C0392747 | lld:lifeskim |
| pubmed-article:12842131 | lifeskim:mentions | umls-concept:C2266866 | lld:lifeskim |
| pubmed-article:12842131 | lifeskim:mentions | umls-concept:C0443172 | lld:lifeskim |
| pubmed-article:12842131 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:12842131 | pubmed:dateCreated | 2003-7-4 | lld:pubmed |
| pubmed-article:12842131 | pubmed:abstractText | The present study was undertaken to examine the effects of the antidepressant, amitriptyline, and brain-derived neurotrophic factor (BDNF) on activator protein-1 (AP-1) DNA binding activity in the rat brain. Acute administration of amitriptyline (5 or 10 mg/kg) initially increased but then decreased AP-1 DNA binding activity in the rat frontal cortex and hippocampus. Chronic administration of amitriptyline (5 or 10 mg/kg, once daily for 3 weeks) initially decreased AP-1 DNA binding activity but ultimately resulted in its persistent elevation in the rat frontal cortex. In contrast, the chronic administration of amitriptyline did not affect the low activity of AP-1 DNA binding in the hippocampus. However, chronic administration of amitriptyline (10 mg/kg, once daily for 3 weeks) significantly increased BDNF protein levels in the hippocampus (by 26.9%) and frontal cortex (by 24.6%). Direct infusion of BDNF (1 microg) into the hippocampal dentate gyrus significantly increased hippocampal AP-1 DNA binding activity. These results suggest that AP-1 transcription factor may be modulated by BDNF and that it may be an important target for the action of antidepressants. | lld:pubmed |
| pubmed-article:12842131 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12842131 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12842131 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12842131 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12842131 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12842131 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12842131 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12842131 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12842131 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12842131 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:12842131 | pubmed:issn | 0028-3908 | lld:pubmed |
| pubmed-article:12842131 | pubmed:author | pubmed-author:OkamotoHH | lld:pubmed |
| pubmed-article:12842131 | pubmed:author | pubmed-author:HashimotoKK | lld:pubmed |
| pubmed-article:12842131 | pubmed:author | pubmed-author:ShirasawaHH | lld:pubmed |
| pubmed-article:12842131 | pubmed:author | pubmed-author:ShimizuEE | lld:pubmed |
| pubmed-article:12842131 | pubmed:author | pubmed-author:ShineGG | lld:pubmed |
| pubmed-article:12842131 | pubmed:author | pubmed-author:LuN MNM | lld:pubmed |
| pubmed-article:12842131 | pubmed:author | pubmed-author:KumakiriCC | lld:pubmed |
| pubmed-article:12842131 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12842131 | pubmed:volume | 45 | lld:pubmed |
| pubmed-article:12842131 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12842131 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12842131 | pubmed:pagination | 251-9 | lld:pubmed |
| pubmed-article:12842131 | pubmed:dateRevised | 2003-11-14 | lld:pubmed |
| pubmed-article:12842131 | pubmed:meshHeading | pubmed-meshheading:12842131... | lld:pubmed |
| pubmed-article:12842131 | pubmed:meshHeading | pubmed-meshheading:12842131... | lld:pubmed |
| pubmed-article:12842131 | pubmed:meshHeading | pubmed-meshheading:12842131... | lld:pubmed |
| pubmed-article:12842131 | pubmed:meshHeading | pubmed-meshheading:12842131... | lld:pubmed |
| pubmed-article:12842131 | pubmed:meshHeading | pubmed-meshheading:12842131... | lld:pubmed |
| pubmed-article:12842131 | pubmed:meshHeading | pubmed-meshheading:12842131... | lld:pubmed |
| pubmed-article:12842131 | pubmed:meshHeading | pubmed-meshheading:12842131... | lld:pubmed |
| pubmed-article:12842131 | pubmed:meshHeading | pubmed-meshheading:12842131... | lld:pubmed |
| pubmed-article:12842131 | pubmed:meshHeading | pubmed-meshheading:12842131... | lld:pubmed |
| pubmed-article:12842131 | pubmed:meshHeading | pubmed-meshheading:12842131... | lld:pubmed |
| pubmed-article:12842131 | pubmed:meshHeading | pubmed-meshheading:12842131... | lld:pubmed |
| pubmed-article:12842131 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12842131 | pubmed:articleTitle | Dynamic changes in AP-1 transcription factor DNA binding activity in rat brain following administration of antidepressant amitriptyline and brain-derived neurotrophic factor. | lld:pubmed |
| pubmed-article:12842131 | pubmed:affiliation | Department of Psychiatry, Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chuou-ku, Chiba 260-8677, Japan. okamo@med.teikyo-u.ac.jp | lld:pubmed |
| pubmed-article:12842131 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12842131 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12842131 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12842131 | lld:pubmed |
