| pubmed-article:12840060 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12840060 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:12840060 | lifeskim:mentions | umls-concept:C1167395 | lld:lifeskim |
| pubmed-article:12840060 | lifeskim:mentions | umls-concept:C1519670 | lld:lifeskim |
| pubmed-article:12840060 | lifeskim:mentions | umls-concept:C0529330 | lld:lifeskim |
| pubmed-article:12840060 | lifeskim:mentions | umls-concept:C0018270 | lld:lifeskim |
| pubmed-article:12840060 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:12840060 | pubmed:dateCreated | 2003-7-3 | lld:pubmed |
| pubmed-article:12840060 | pubmed:abstractText | Although the renin angiotensin system (RAS) is a major regulator of vascular homeostasis, the role of the RAS in tumor angiogenesis is little understood. Here we show that host angiotensin II (ATII) type 1 (AT1) receptor plays an important role in angiogenesis and growth of tumor cells engrafted in mice. Subcutaneous B16-F1 melanoma-induced angiogenesis as assessed by tissue capillary density and microangiography was prominent in WT mice but was reduced in AT1a receptor-deficient (AT1a-/-) mice. Consequently, tumor growth rate was significantly slower, and the mouse survival rate was greater, in AT1a-/- mice than in WT mice. Tumor growth was also reduced in WT mice treated with TCV-116, a selective blocker of AT1 receptor. Because the beta-galactosidase gene was inserted into the AT1a gene locus in AT1a-/- mice, the site of beta-galactosidase expression represents the AT1a receptor expression in these mutant mice. In tumor-implanted AT1a-/- mice, the major site of the beta-galactosidase expression was macrophages in tissues surrounding tumors. Moreover, the number of infiltrated macrophages was significantly lower in AT1a-/- mice than in WT mice, and double-immunofluorescence staining revealed that these macrophages expressed VEGF protein intensively. Therefore, the host ATII-AT1 receptor pathway supports tumor-associated macrophage infiltration, which results in enhanced tissue VEGF protein levels. The host ATII-AT1 receptor pathway thereby plays important roles in tumor-related angiogenesis and growth in vivo. | lld:pubmed |
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| pubmed-article:12840060 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12840060 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12840060 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:12840060 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:12840060 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12840060 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:12840060 | pubmed:issn | 0021-9738 | lld:pubmed |
| pubmed-article:12840060 | pubmed:author | pubmed-author:IkedaHisaoH | lld:pubmed |
| pubmed-article:12840060 | pubmed:author | pubmed-author:ImaizumiTsuto... | lld:pubmed |
| pubmed-article:12840060 | pubmed:author | pubmed-author:MuroharaToyoa... | lld:pubmed |
| pubmed-article:12840060 | pubmed:author | pubmed-author:SugayaTakeshi... | lld:pubmed |
| pubmed-article:12840060 | pubmed:author | pubmed-author:ShimadaToshif... | lld:pubmed |
| pubmed-article:12840060 | pubmed:author | pubmed-author:ShintaniSatos... | lld:pubmed |
| pubmed-article:12840060 | pubmed:author | pubmed-author:MatsuishiToyo... | lld:pubmed |
| pubmed-article:12840060 | pubmed:author | pubmed-author:IshiiMasahiro... | lld:pubmed |
| pubmed-article:12840060 | pubmed:author | pubmed-author:AkagiTeijiT | lld:pubmed |
| pubmed-article:12840060 | pubmed:author | pubmed-author:SasakiKen-Ich... | lld:pubmed |
| pubmed-article:12840060 | pubmed:author | pubmed-author:EgamiKimiyasu... | lld:pubmed |
| pubmed-article:12840060 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12840060 | pubmed:volume | 112 | lld:pubmed |
| pubmed-article:12840060 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12840060 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12840060 | pubmed:pagination | 67-75 | lld:pubmed |
| pubmed-article:12840060 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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