| pubmed-article:12837752 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12837752 | lifeskim:mentions | umls-concept:C0027651 | lld:lifeskim |
| pubmed-article:12837752 | lifeskim:mentions | umls-concept:C0302600 | lld:lifeskim |
| pubmed-article:12837752 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:12837752 | lifeskim:mentions | umls-concept:C0762871 | lld:lifeskim |
| pubmed-article:12837752 | lifeskim:mentions | umls-concept:C1336647 | lld:lifeskim |
| pubmed-article:12837752 | lifeskim:mentions | umls-concept:C1527148 | lld:lifeskim |
| pubmed-article:12837752 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:12837752 | lifeskim:mentions | umls-concept:C0678594 | lld:lifeskim |
| pubmed-article:12837752 | pubmed:issue | 37 | lld:pubmed |
| pubmed-article:12837752 | pubmed:dateCreated | 2003-9-8 | lld:pubmed |
| pubmed-article:12837752 | pubmed:abstractText | Blocking angiogenesis is an attractive strategy to inhibit tumor growth, invasion, and metastasis. We describe here the structure and the biological action of a new cyclic peptide derived from vascular endothelial growth factor (VEGF). This 17-amino acid molecule designated cyclopeptidic vascular endothelial growth inhibitor (cyclo-VEGI, CBO-P11) encompasses residues 79-93 of VEGF which are involved in the interaction with VEGF receptor-2. In aqueous solution, cyclo-VEGI presents a propensity to adopt a helix conformation that was largely unexpected because only beta-sheet structures or random coil conformations have been observed for macrocyclic peptides. Cyclo-VEGI inhibits binding of iodinated VEGF165 to endothelial cells, endothelial cells proliferation, migration, and signaling induced by VEGF165. This peptide also exhibits anti-angiogenic activity in vivo on the differentiated chicken chorioallantoic membrane. Furthermore, cyclo-VEGI significantly blocks the growth of established intracranial glioma in nude and syngeneic mice and improves survival without side effects. Taken together, these results suggest that cyclo-VEGI is an attractive candidate for the development of novel angiogenesis inhibitor molecules useful for the treatment of cancer and other angiogenesis-related diseases. | lld:pubmed |
| pubmed-article:12837752 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12837752 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12837752 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12837752 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:12837752 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12837752 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:12837752 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12837752 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12837752 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:12837752 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:12837752 | pubmed:author | pubmed-author:ConvertOdileO | lld:pubmed |
| pubmed-article:12837752 | pubmed:author | pubmed-author:LequinOlivier... | lld:pubmed |
| pubmed-article:12837752 | pubmed:author | pubmed-author:HagedornMarti... | lld:pubmed |
| pubmed-article:12837752 | pubmed:author | pubmed-author:CostaFrancesc... | lld:pubmed |
| pubmed-article:12837752 | pubmed:author | pubmed-author:BikfalviAndre... | lld:pubmed |
| pubmed-article:12837752 | pubmed:author | pubmed-author:BelloLorenzoL | lld:pubmed |
| pubmed-article:12837752 | pubmed:author | pubmed-author:CaronzoloDari... | lld:pubmed |
| pubmed-article:12837752 | pubmed:author | pubmed-author:ZilberbergLio... | lld:pubmed |
| pubmed-article:12837752 | pubmed:author | pubmed-author:CanronXavierX | lld:pubmed |
| pubmed-article:12837752 | pubmed:author | pubmed-author:DelerisGérard... | lld:pubmed |
| pubmed-article:12837752 | pubmed:author | pubmed-author:ShinkarukSvet... | lld:pubmed |
| pubmed-article:12837752 | pubmed:author | pubmed-author:RousseauBenoi... | lld:pubmed |
| pubmed-article:12837752 | pubmed:author | pubmed-author:BalkeMauriceM | lld:pubmed |
| pubmed-article:12837752 | pubmed:author | pubmed-author:LaïnGeorgesG | lld:pubmed |
| pubmed-article:12837752 | pubmed:author | pubmed-author:GionnetKarine... | lld:pubmed |
| pubmed-article:12837752 | pubmed:author | pubmed-author:GoncalvèsMari... | lld:pubmed |
| pubmed-article:12837752 | pubmed:author | pubmed-author:BayleMireille... | lld:pubmed |
| pubmed-article:12837752 | pubmed:author | pubmed-author:ChassaingGera... | lld:pubmed |
| pubmed-article:12837752 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12837752 | pubmed:day | 12 | lld:pubmed |
| pubmed-article:12837752 | pubmed:volume | 278 | lld:pubmed |
| pubmed-article:12837752 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12837752 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12837752 | pubmed:pagination | 35564-73 | lld:pubmed |
| pubmed-article:12837752 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:12837752 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12837752 | pubmed:articleTitle | Structure and inhibitory effects on angiogenesis and tumor development of a new vascular endothelial growth inhibitor. | lld:pubmed |
| pubmed-article:12837752 | pubmed:affiliation | Molecular Angiogenesis Laboratory, INSERM E 0113, Université de Bordeaux 1, 33405 Talence, France. | lld:pubmed |
| pubmed-article:12837752 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12837752 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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