Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:12837019rdf:typepubmed:Citationlld:pubmed
pubmed-article:12837019lifeskim:mentionsumls-concept:C0036857lld:lifeskim
pubmed-article:12837019lifeskim:mentionsumls-concept:C0031485lld:lifeskim
pubmed-article:12837019lifeskim:mentionsumls-concept:C0025914lld:lifeskim
pubmed-article:12837019lifeskim:mentionsumls-concept:C0026809lld:lifeskim
pubmed-article:12837019lifeskim:mentionsumls-concept:C0026336lld:lifeskim
pubmed-article:12837019lifeskim:mentionsumls-concept:C0004927lld:lifeskim
pubmed-article:12837019lifeskim:mentionsumls-concept:C0314603lld:lifeskim
pubmed-article:12837019lifeskim:mentionsumls-concept:C1979963lld:lifeskim
pubmed-article:12837019lifeskim:mentionsumls-concept:C1555903lld:lifeskim
pubmed-article:12837019lifeskim:mentionsumls-concept:C2003903lld:lifeskim
pubmed-article:12837019pubmed:issue3lld:pubmed
pubmed-article:12837019pubmed:dateCreated2003-7-2lld:pubmed
pubmed-article:12837019pubmed:abstractTextPah(enu2) mice, created by chemically induced genetic mutation, are characterized by biochemical phenotypes closely resembling untreated human phenylketonuria (PKU). However, studies conducted in adult Pah(enu2) mice have shown no indices of the severe mental retardation that characterizes untreated PKU. The present experiments explored recognition of novel spatial and non-spatial information in Pah(enu2) mice by two nonassociative tests that do not use explicit reinforcement and avoid lengthy training. Moreover, we evaluated emotional reactivity by the Elevated Plus Maze. Finally, the performance of affected mutants was compared with that of their unaffected and heterozygous littermates and also with that of mice of the C57BL/6 (C57) inbred strain, an increasingly used background for genetic targeted organisms, and with DBA/2 (DBA) mice, known for their nonpathological deficits in spatial learning. The results demonstrated that mutant Pah(enu2) mice are characterized by deficits involving both spatial and nonspatial recognition, that are not related to motor impairment or to high emotional reactivity to novelty. These results indicate that Pah(enu2) mice show pathological cognitive deficits and support their use to test hypotheses about neurodevelopmental disturbances involved in mental retardation.lld:pubmed
pubmed-article:12837019pubmed:languageenglld:pubmed
pubmed-article:12837019pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12837019pubmed:citationSubsetIMlld:pubmed
pubmed-article:12837019pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12837019pubmed:statusMEDLINElld:pubmed
pubmed-article:12837019pubmed:monthMaylld:pubmed
pubmed-article:12837019pubmed:issn0001-8244lld:pubmed
pubmed-article:12837019pubmed:authorpubmed-author:VenturaRossel...lld:pubmed
pubmed-article:12837019pubmed:authorpubmed-author:Puglisi-Alleg...lld:pubmed
pubmed-article:12837019pubmed:authorpubmed-author:CabibSimonaSlld:pubmed
pubmed-article:12837019pubmed:authorpubmed-author:RomanoValenti...lld:pubmed
pubmed-article:12837019pubmed:authorpubmed-author:PascucciTizia...lld:pubmed
pubmed-article:12837019pubmed:issnTypePrintlld:pubmed
pubmed-article:12837019pubmed:volume33lld:pubmed
pubmed-article:12837019pubmed:ownerNLMlld:pubmed
pubmed-article:12837019pubmed:authorsCompleteYlld:pubmed
pubmed-article:12837019pubmed:pagination301-10lld:pubmed
pubmed-article:12837019pubmed:dateRevised2011-11-17lld:pubmed
pubmed-article:12837019pubmed:meshHeadingpubmed-meshheading:12837019...lld:pubmed
pubmed-article:12837019pubmed:meshHeadingpubmed-meshheading:12837019...lld:pubmed
pubmed-article:12837019pubmed:meshHeadingpubmed-meshheading:12837019...lld:pubmed
pubmed-article:12837019pubmed:meshHeadingpubmed-meshheading:12837019...lld:pubmed
pubmed-article:12837019pubmed:meshHeadingpubmed-meshheading:12837019...lld:pubmed
pubmed-article:12837019pubmed:meshHeadingpubmed-meshheading:12837019...lld:pubmed
pubmed-article:12837019pubmed:meshHeadingpubmed-meshheading:12837019...lld:pubmed
pubmed-article:12837019pubmed:meshHeadingpubmed-meshheading:12837019...lld:pubmed
pubmed-article:12837019pubmed:meshHeadingpubmed-meshheading:12837019...lld:pubmed
pubmed-article:12837019pubmed:meshHeadingpubmed-meshheading:12837019...lld:pubmed
pubmed-article:12837019pubmed:meshHeadingpubmed-meshheading:12837019...lld:pubmed
pubmed-article:12837019pubmed:meshHeadingpubmed-meshheading:12837019...lld:pubmed
pubmed-article:12837019pubmed:meshHeadingpubmed-meshheading:12837019...lld:pubmed
pubmed-article:12837019pubmed:meshHeadingpubmed-meshheading:12837019...lld:pubmed
pubmed-article:12837019pubmed:meshHeadingpubmed-meshheading:12837019...lld:pubmed
pubmed-article:12837019pubmed:year2003lld:pubmed
pubmed-article:12837019pubmed:articleTitleThe behavioral profile of severe mental retardation in a genetic mouse model of phenylketonuria.lld:pubmed
pubmed-article:12837019pubmed:affiliationDipartimento di Psicologia, Università "La Sapienza," via dei Marsi 78, Rome 1-00195, Italy. simona.cabib@uniroma1.itlld:pubmed
pubmed-article:12837019pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:12837019pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
entrez-gene:18478entrezgene:pubmedpubmed-article:12837019lld:entrezgene
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12837019lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12837019lld:pubmed