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12835092

Source:http://linkedlifedata.com/resource/pubmed/id/12835092

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pubmed-article:12835092rdf:typepubmed:Citationlld:pubmed
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pubmed-article:12835092pubmed:issue4lld:pubmed
pubmed-article:12835092pubmed:dateCreated2003-7-1lld:pubmed
pubmed-article:12835092pubmed:abstractTextIn three experiments the acute effects of clonidine administration upon locomotor and rearing behaviour of mice pretreated with the selective noradrenaline (NA) neurotoxin, DSP4 (1 x 75 mg/kg, i.p.) 10-12 days previously, were studied. Clonidine (0.01, 0.05, 0.25, 1.25 and 3.0 mg/kg, i.p.) induced a dose-dependent reduction of motor activity during the initial 30 min of testing in both DSP4-treated and control mice; this effect was attenuated by DSP4 treatment in the 0.01, 0.05, 0.25 and 3.0 mg/kg dose groups. By the third 30-min period of testing (60-90 min), each clonidine dose group, except the highest (3.0 mg/kg) dose for locomotion and the two highest (1.25 and 3.0 mg/kg) doses for rearing, induced increases in motor activity in the control mice. In DSP4-treated mice, a large increase in locomotor counts was produced by the 0.05 mg/kg dose of clonidine with lesser increases induced by the 0.01 mg/kg dose group, whereas a lesser effect of the 0.05 mg/kg group (30-60 min) was obtained for rearing but a larger effect of the 0.25 mg/kg group (60-90 min). Yohimbine (0.5 mg/kg, i.p., 15 min before clonidine) attenuated the suppressive effects of clonidine (0.01 and 0.05 mg/kg) during the initial 30 min of testing and markedly increased locomotor and rearing counts, both by itself and in combination with each dose of clonidine, in both DSP4-treated and control mice over the following 90 min of testing. Yohimbine treatment attenuated the large increase in locomotor counts induced by the 0.05 mg/kg dose of clonidine in the NA-denervated mice. Dihydroergotamine (0.5 mg/kg, i.p., 15 min before clonidine) did not antagonise either the initial suppressive effect or the later supersensitivity effect of the 0.05 mg/kg dose of clonidine. DSP4 treatment by itself reduced motor activity. The effects of clonidine, dose- and time-dependently, by itself or in co-administration with alpha-adrenoceptor antagonists, in DSP4-treated or control mice displayed denervation-induced supersensitivity that appear to reflect mainly postsynaptic alpha2-adrenoceptor mediation.lld:pubmed
pubmed-article:12835092pubmed:languageenglld:pubmed
pubmed-article:12835092pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12835092pubmed:statusPubMed-not-MEDLINElld:pubmed
pubmed-article:12835092pubmed:monthAprlld:pubmed
pubmed-article:12835092pubmed:issn1029-8428lld:pubmed
pubmed-article:12835092pubmed:authorpubmed-author:FredrikssonAAlld:pubmed
pubmed-article:12835092pubmed:authorpubmed-author:ArcherTTlld:pubmed
pubmed-article:12835092pubmed:issnTypePrintlld:pubmed
pubmed-article:12835092pubmed:volume1lld:pubmed
pubmed-article:12835092pubmed:ownerNLMlld:pubmed
pubmed-article:12835092pubmed:authorsCompleteYlld:pubmed
pubmed-article:12835092pubmed:pagination235-47lld:pubmed
pubmed-article:12835092pubmed:year2000lld:pubmed
pubmed-article:12835092pubmed:articleTitleEffects of clonidine and alpha-adrenoceptor antagonists on motor activity in DSP4-treated mice I: dose-, time- and parameter-dependency.lld:pubmed
pubmed-article:12835092pubmed:affiliationDepartment of Psychology, University of Göteborg, Sweden. trevor.archer@psy.gu.selld:pubmed
pubmed-article:12835092pubmed:publicationTypeJournal Articlelld:pubmed