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pubmed-article:12833454pubmed:abstractTextA small proportion of patients with colorectal carcinoma (CRC) have synchronous tumors at the time of diagnosis. A subset of sporadic CRCs display microsatellite instability (MSI) that is associated with MLH1 silencing due to promoter methylation. In the current study, the authors investigated the proportion of tumors with MSI in patients with synchronous colorectal carcinoma (SCRC) and the concordance in MSI status among tumors in a given individual. In addition, the authors examined MLH1 and MSH2 expression and MLH1 promoter methylation in SCRCs.lld:pubmed
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pubmed-article:12833454pubmed:authorpubmed-author:QuiHongmingHlld:pubmed
pubmed-article:12833454pubmed:copyrightInfoCopyright 2003 American Cancer Society.DOI 10.1002/cncr.11445lld:pubmed
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pubmed-article:12833454pubmed:pagination48-54lld:pubmed
pubmed-article:12833454pubmed:dateRevised2007-11-15lld:pubmed
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pubmed-article:12833454pubmed:year2003lld:pubmed
pubmed-article:12833454pubmed:articleTitleEvidence of a preferred molecular pathway in patients with synchronous colorectal cancer.lld:pubmed
pubmed-article:12833454pubmed:affiliationDepartment of Surgery, University of Minnesota Cancer Center, Minneapolis, Minnesota, USA.lld:pubmed
pubmed-article:12833454pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:12833454pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed