| pubmed-article:1282816 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1282816 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:1282816 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:1282816 | lifeskim:mentions | umls-concept:C0227525 | lld:lifeskim |
| pubmed-article:1282816 | lifeskim:mentions | umls-concept:C0075193 | lld:lifeskim |
| pubmed-article:1282816 | lifeskim:mentions | umls-concept:C1150572 | lld:lifeskim |
| pubmed-article:1282816 | lifeskim:mentions | umls-concept:C0547047 | lld:lifeskim |
| pubmed-article:1282816 | lifeskim:mentions | umls-concept:C0070750 | lld:lifeskim |
| pubmed-article:1282816 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:1282816 | pubmed:dateCreated | 1993-2-5 | lld:pubmed |
| pubmed-article:1282816 | pubmed:abstractText | Two main forms of protein kinase C (PKC 1 and PKC 2) are detected in homogenates of rat hepatocytes using DEAE-cellulose column chromatography. The activity of these forms paradoxically, is rapidly decreased by treatment in vivo with phorbol myristate acetate (PMA). The dose-response curves to PMA for decreasing the activities of PKC 1 and 2 were shifted to the right by the potent and selective PKC inhibitors, staurosporine and calphostin-C. The decreases induced by 100 nM PMA were dose-dependently blocked by these inhibitors. It is concluded that activation of PKC is required and precedes such decreases in activity induced by the active phorbol ester. | lld:pubmed |
| pubmed-article:1282816 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1282816 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1282816 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1282816 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1282816 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1282816 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1282816 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1282816 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1282816 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1282816 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1282816 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1282816 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:1282816 | pubmed:issn | 0158-5231 | lld:pubmed |
| pubmed-article:1282816 | pubmed:author | pubmed-author:García-SáinzJ... | lld:pubmed |
| pubmed-article:1282816 | pubmed:author | pubmed-author:Robles-Flores... | lld:pubmed |
| pubmed-article:1282816 | pubmed:author | pubmed-author:López-GómezF... | lld:pubmed |
| pubmed-article:1282816 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1282816 | pubmed:volume | 28 | lld:pubmed |
| pubmed-article:1282816 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1282816 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1282816 | pubmed:pagination | 761-6 | lld:pubmed |
| pubmed-article:1282816 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
| pubmed-article:1282816 | pubmed:meshHeading | pubmed-meshheading:1282816-... | lld:pubmed |
| pubmed-article:1282816 | pubmed:meshHeading | pubmed-meshheading:1282816-... | lld:pubmed |
| pubmed-article:1282816 | pubmed:meshHeading | pubmed-meshheading:1282816-... | lld:pubmed |
| pubmed-article:1282816 | pubmed:meshHeading | pubmed-meshheading:1282816-... | lld:pubmed |
| pubmed-article:1282816 | pubmed:meshHeading | pubmed-meshheading:1282816-... | lld:pubmed |
| pubmed-article:1282816 | pubmed:meshHeading | pubmed-meshheading:1282816-... | lld:pubmed |
| pubmed-article:1282816 | pubmed:meshHeading | pubmed-meshheading:1282816-... | lld:pubmed |
| pubmed-article:1282816 | pubmed:meshHeading | pubmed-meshheading:1282816-... | lld:pubmed |
| pubmed-article:1282816 | pubmed:meshHeading | pubmed-meshheading:1282816-... | lld:pubmed |
| pubmed-article:1282816 | pubmed:meshHeading | pubmed-meshheading:1282816-... | lld:pubmed |
| pubmed-article:1282816 | pubmed:meshHeading | pubmed-meshheading:1282816-... | lld:pubmed |
| pubmed-article:1282816 | pubmed:meshHeading | pubmed-meshheading:1282816-... | lld:pubmed |
| pubmed-article:1282816 | pubmed:meshHeading | pubmed-meshheading:1282816-... | lld:pubmed |
| pubmed-article:1282816 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1282816 | pubmed:articleTitle | Staurosporine and calphostin-C inhibit the phorbol ester-induced decrease of protein kinase C activity in rat hepatocytes. | lld:pubmed |
| pubmed-article:1282816 | pubmed:affiliation | Departamento de Bioenergética, Facultad de Medicina, Universidad Nacional Autónoma de México, D.F. | lld:pubmed |
| pubmed-article:1282816 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1282816 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
